首页> 外文会议>Optimization and Systems Biology >Identification of intracellular kinetic parameters in continuous bioconversion of glycerol by Klebsiella pneumoniae
【24h】

Identification of intracellular kinetic parameters in continuous bioconversion of glycerol by Klebsiella pneumoniae

机译:肺炎克雷伯氏菌连续生物转化甘油的细胞内动力学参数的确定

获取原文
获取原文并翻译 | 示例

摘要

In this paper, we propose a hybrid nonlinear dynamical system to describe the concentration changes of extracellular and intracellular substances of glycerol bioconversion to 1,3-propanedol (1,3-PD) in microbial continuous cultures. It is proved that the solution to the system exists and is continuous with respect to kinetic parameters. Subsequently, a novel quantitative definition of biological robustness is investigated. We present a performance index based on experiment data of extracellular concentrations and biological robustness. Taking the proposed hybrid nonlinear dynamical system as a constraint, we establish an identification model to determine the most reasonable metabolic pathway and optimal kinetic parameters. The identifiability of the proposed model is also ascertained. This work provides theoretical basis for future numerical simulation and optimization computation.
机译:在本文中,我们提出了一个混合非线性动力学系统,以描述在微生物连续培养中,甘油生物转化为1,3-丙烷(1,3-PD)的细胞外和细胞内物质的浓度变化。事实证明,该系统的解存在并且相对于动力学参数是连续的。随后,研究了生物学鲁棒性的新的定量定义。我们提出了基于细胞外浓度和生物学鲁棒性的实验数据的性能指标。以提出的混合非线性动力学系统为约束,我们建立了一个识别模型,以确定最合理的代谢途径和最佳动力学参数。还确定了所提出模型的可识别性。这项工作为今后的数值模拟和优化计算提供了理论依据。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号