Structural Insights into the Mode of Actions of and Resistance to Neonicotinoids

机译：对新烟碱类药物的作用方式和耐药性的结构见解

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@@ Neonicotinoids are neutotoxic insecticides targeting nicotinic acetylcholine receptors (nAChRs). They not only activate the cation-permeable ion channels of nAChRs, resulting in depolarization of nerve membranes, but can also block a subclass of nAChRs. Whether the actions are agonistic or antagonistic, neonicotinoids selectively act on insect nAChRs.

机译：新烟碱类是针对烟碱样乙酰胆碱受体（nAChRs）的中毒杀虫剂。它们不仅激活nAChRs的阳离子可渗透离子通道，导致神经膜去极化，而且还可以阻断nAChRs的一个亚类。无论作用是拮抗作用还是拮抗作用，新烟碱类药物选择性地作用于昆虫nAChRs。

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来源
《Proceedings of 4th international symposium on pesticides and environmental safety amp; 5th pan Pacific confernce on pesticide science amp; 8th international workshop on crop protection chemistry and regulatory harmonization》|2012年|399|共1页
会议地点 Beijing(CN)
作者
Kazuhiko Matsuda;
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作者单位

Department of Applied Biological Chemistry, Faculty of Agriculture, Kinki University;

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会议组织
原文格式 PDF
正文语种 eng
中图分类植物化学保护理论;农用化学物质、有毒化学物质污染及其防治;
关键词
neonicotinoids; mode of actions; resistance;

机译：新烟碱;作用方式;抗药性;

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1. Diverse actions and target-site selectivity of neonicotinoids: structural insights. [J] . Matsuda K, Kanaoka S, Akamatsu M Molecular pharmacology. . 2009,第1期

机译：新烟碱的多种作用和靶位选择性：结构见解。
2. Structural insights into the theoretical model of Plasmodium falciparum multi drug resistance 1 protein (PfMDR1) and its interaction with phytochemicals as efficacious antimalarial drugs: an in silico and in vitro approach [J] . Patel Saumya K., Jha Prakash C., Jasrai Yogesh, Journal of Biomolecular Structure and Dynamics . 2015,第Suppla期

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3. Structural insights into mode of actions of novel substituted 4- and 6-azaindole-3-carboxamides analogs as renin inhibitors: molecular modeling studies [J] . Sharma Mukesh C. Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents . 2015,第3期

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4. Structural Insights into the Mode of Actions of and Resistance to Neonicotinoids [C] . Kazuhiko Matsuda International workshop on crop protection chemistry and regulatory harmonization . 2012

机译：结构洞察和抗Neonicotinoids的动作模式
5. Structural insights into the function of the Arabidopsis protein RIN4, a multi-regulator of plant resistance against bacterial pathogens. [D] . da Cunha, Luis C. V. 2009

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6. Diverse Actions and Target-Site Selectivity of Neonicotinoids: Structural Insights [O] . Kazuhiko Matsuda, Satoshi Kanaoka, Miki Akamatsu, -1

机译：新烟碱的不同作用和靶位选择性：结构见解
7. Diverse Actions and Target-Site Selectivity of Neonicotinoids: Structural Insights [O] . Matsuda, Kazuhiko, Kanaoka, Satoshi, Akamatsu, Miki, 2009

机译：新烟碱的不同作用和靶位选择性：结构见解

Structural Insights into the Mode of Actions of and Resistance to Neonicotinoids

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