Optical Methods for the analysis of dermatopharmacokinetics

机译：光学方法分析皮肤药代动力学

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The method of tape stripping in combination with spectroscopic measurements is a simple and noninvasive method for the analysis of dermatopharmacokinetics of cosmetic products and topically applied drugs. The absorbance at 430 nm was used for the characterization of the amount of corneocytes on the tape strips. It was compared to the increase of weight of the tapes after removing them from the skin surface. The penetration profiles of two UV filter substances used in sunscreens were determined. The combined method of tape stripping and spectroscopic measurements can be also used for the investigation of the dermatopharmacokinetics of topically applied drugs passing through the skin. Differences in the penetration profiles of the steroid compound clobetasol, applied in the same concentration in different formulations on the skin are presented.

机译：胶带剥离与光谱测量相结合的方法是一种简单且非侵入性的方法，用于分析化妆品和局部使用药物的皮肤药代动力学。 430nm处的吸光度用于表征条带上的角质细胞的数量。将其与从皮肤表面去除胶带后重量的增加进行比较。确定了防晒霜中使用的两种紫外线过滤剂物质的渗透曲线。胶带剥离和光谱测量的组合方法也可以用于研究通过皮肤的局部施用药物的皮肤药代动力学。呈现了以相同浓度在皮肤上以不同制剂施用的类固醇化合物氯倍他索的渗透曲线的差异。

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来源
《Saratov Fall Meeting 2001: Optical Technologies in Biophysics and Medicine Ⅲ Oct 2-5, 2001 Saratov, Russia》|2001年|p.1-8|共8页
会议地点 Saratov(US)
作者
J. Lademann; H.-J. Weigmann; R. v. Pelchrzim; W. Sterry;
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作者单位

Center of Experimental and Applied Cutaneous Physiology (CCP) at the Dermatological Clinic of the Charite Berlin;

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原文格式 PDF
正文语种 eng
中图分类物理学;
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Optical Methods for the analysis of dermatopharmacokinetics

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