• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>The Sixth Symposium on Environmental Toxicology and Risk Assessment was Presented in Orlando, FL on 15-18 April, 1996. >Predicting dermal absorption from contact with chemically contaminated soils
【24h】

Predicting dermal absorption from contact with chemically contaminated soils

机译：与化学污染的土壤接触，预测皮肤吸收

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Dermal absorption from contaminated soils is poorly understood and more experimental study is needed. To guide selection of experimental variables for testing and to facilitate interpretation of resulting data, we have developed mathematical models describing dermal absorption of organic chemicals (1.59<=log_(10)K_(o/w) <=5.53 and MW<=700) from contaminated soils (with about 0.2percent or more organic carbon and with clay fractions which are less than 60 times the weight fraction of organic carbon). Assumptions about the kinetics of soil desorption relative to dermal absorption must be included in these models, although little quantitative information is presently available. Consequently, the models presented here represent two extreme situations in which either the dermal barrier, or the soil controls the rate of dermal absorption. For estimating the relative effect of changing exposure conditions (e.g., changes in soil loading, contamination levels, chemical, etc.), the predictions from both models are generally consistent with experimental results. However, the models assuming fast soil release kinetics perict more absorption than was observed experimentally for lindane and 2,4-D. This suggests that soil release kinetics may limit the amount of dermal absorption in at least some situations.
机译：人们对污染土壤的皮肤吸收知之甚少，需要进行更多的实验研究。为了指导选择实验变量进行测试并有助于解释结果数据，我们开发了描述有机化学物质皮肤吸收的数学模型（1.59 <= log_（10）K_（o / w）<= 5.53和MW <= 700）来自受污染的土壤（有机碳含量约0.2％或更多，粘土含量小于有机碳重量分数的60倍）。这些模型中必须包括土壤脱附相对于真皮吸收的动力学假设，尽管目前尚缺乏定量信息。因此，这里介绍的模型代表了两种极端情况，即真皮屏障或土壤控制真皮吸收速率。为了估算暴露条件变化的相对影响（例如土壤负荷，污染水平，化学物质等的变化），两种模型的预测通常与实验结果一致。然而，假设快速污垢释放动力学的模型吸收的水合物比对林丹和2,4-D的实验观察到的要大。这表明污垢释放动力学至少在某些情况下可能会限制真皮吸收量。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号