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Non-invasive monitoring of acute intracranial mass lesions using ultrasonic fingerprinting

机译:超声指纹图谱对急性颅内肿块的无创监测

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摘要

Potentially dangerous neurological changes in shock-trauma patients are currently monitored by computer-aided X-ray tomography which is prohibitively expensive and even dangerous for long-term, e.g., comatose, patients. By ultrasound, only low-frequency "diffuse" ultrasonic inspection is feasible through the skull so that the details are irreversible lost in the essentially random scattering process. In order to overcome this inherent limitation, we adapted a continuous computer-controlled ultrasonic monitoring system based on the ultrasonic fingerprinting method originally developed for materials characterization purposes in the nuclear, civil engineering, and aerospace industries. An ultrasonic detector directed at the general area of interest can be used to record and repeatedly update the personal signature of the patient, which is then used as an "ultrasonic fingerprint." Any abrupt change in this signature indicates the immediate need for further investigation by CT or other sophisticated diagnostic tools. Experimental studies were conducted on both a human skull/gelatin phantom and 5 intact human cadavers. Ultrasonic fingerprinting could detect the secondary effects of volumetric changes occurring at multiple locations and the average detectable volumes of mass lesions were found to be lower than indications for surgical intervention.
机译:当前,通过计算机辅助X射线断层摄影术监测休克创伤患者中潜在的危险神经学变化,这是昂贵的,甚至对于长期例如昏迷的患者也是危险的。通过超声检查,只有低频“漫射”超声检查可通过颅骨进行检查,以使细节在基本随机的散射过程中不可逆地丢失。为了克服此固有的局限性,我们基于最初用于核材料,民用工程和航空航天业的材料表征目的而开发的超声指纹识别方法,改编了连续计算机控制的超声监测系统。指向一般感兴趣区域的超声检测器可用于记录并重复更新患者的个人签名,然后将其用作“超声波指纹”。此签名的任何突然更改都表明立即需要通过CT或其他复杂的诊断工具进行进一步检查。对人的头骨/明胶模型和5个完整的人尸体进行了实验研究。超声指纹图谱可以检测在多个位置发生的体积变化的次要作用,发现肿块病变的平均可检测体积低于手术干预的指征。

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