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首页> 外文会议>Tropical and subtropical fruits: flavors, color, and health benefits >Bioactive Compounds in Moringa oleifera: Isolation, Structure Elucidation, and Their Antiproliferative Properties
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Bioactive Compounds in Moringa oleifera: Isolation, Structure Elucidation, and Their Antiproliferative Properties

机译：辣木中的生物活性化合物：分离，结构阐明及其抗增殖特性。

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摘要

A systematic study for the isolation and structure elucidation using thin-layer chromatography (TLC)/electrospray ionization mass spectrometry (ESI-MS) of microwaved methanolic extract of different sections of the tropical fruit Moringa oleifera is described. Different tissues of Moringa oleifera such as seed coat (inner skin skeleton), pulp and seeds when subjected to electrospray ionization mass spectrometry provided 4-(±-L-rhamnopyranosyloxy) benzyl glucosinolate and its corresponding three mono acetyl isomers. Benzyl glucosinolate at m/z 408, its parahydroxy derivative and its higher homologue are also profiled. Biological active myrosinase hydrolyzed products, 1-iso thiocyanate-(5-methylsulfinylpentane), and 1-isothiocyanato-3-methylsulfonyl-propane presumably by the hydrolysis catalyzed by myrosinase were also characterized. The identification of O-ethyl-4-[α-L-rhamnosyloxy benzyl]-carbamate from M. oleifera pulp provided m/z 341 is also described. Collision-induced dissociation mass spectra of anions present in Moringa oleifera exhibited product ion at m/z 97, characteristic of sulfate moiety (HSO_4~-) in the molecular structure of glucosinolates. The proliferation inhibitory effects of Moringa oleifera seed, seed coat, pulp (inner skin skeleton) and skin on human colon cancer HT-29 cells and Caco-2 cells are investigated in these studies.
机译：描述了使用薄层色谱（TLC）/电喷雾电离质谱（ESI-MS）对热带水果辣木不同部位的微波甲醇提取物进行分离和结构解析的系统研究。辣木的不同组织，例如种皮（皮肤内骨架），果肉和种子，在进行电喷雾电离质谱分析时，可提供4-（±-L-鼠李糖基吡喃糖基氧基）芥子油苷及其相应的三种单乙酰基异构体。还对m / z 408的芥子油酰基苄酯，其对羟基衍生物及其较高的同系物进行了分析。还表征了可能由黑芥子酶催化的水解的生物活性黑芥子酶水解产物，1-异硫氰酸酯-（5-甲基亚磺酰基戊烷）和1-异硫氰酸根-3-甲基磺酰基丙烷。还描述了在m / z 341条件下从油果分支纸浆中鉴定O-乙基-4- [α-L-鼠李糖氧基苄基]氨基甲酸酯。辣木中阴离子的碰撞诱导解离质谱在m / z 97处显示出产物离子，这是芥子油苷分子结构中的硫酸盐部分（HSO_4-）的特征。在这些研究中，研究了辣木种子，种皮，果肉（皮肤内部骨架）和皮肤对人结肠癌HT-29细胞和Caco-2细胞的增殖抑制作用。

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  • 会议地点 Denver CO(US)
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    Bishambar Dayal; Vineela Reddy Yannamreddy; Ritesh Amin; Michael A. Lea; Athula B. Attygalle;

  • 作者单位

    Department of Medicine, UMDNJ-New Jersey Medical School,Newark, New Jersey 07103,Department of Biochemistry and Molecular Biology, UMDNJ-New Jersey Medical School, Newark, New Jersey 07103;

    Department of Biochemistry and Molecular Biology, UMDNJ-New Jersey Medical School, Newark, New Jersey 07103;

    Department of Biochemistry and Molecular Biology, UMDNJ-New Jersey Medical School, Newark, New Jersey 07103;

    Department of Biochemistry and Molecular Biology, UMDNJ-New Jersey Medical School, Newark, New Jersey 07103;

    Department of Chemistry, Chemical Biology and Biomedical Engineering,Stevens Institute of Technology, Hoboken, New Jersey 07030;

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