文摘
英文文摘
论文说明：ABBREVIATION
声明
Ⅰ.Genus Cynanchum: A Review of Chemical Constituents and Pharmacological Activities
1.1 Introduction
1.2 Chemical Constituents
1.2.1 Steroids
1.2.2 Alkaloids
1.2.3 Acetophenones
1.2.4 Triterpenoids
1.2.5 Flavonoids
1.2.6 Others Constituents
1.3 Pharmacological Activities
1.3.1 Anti-tumor Activity
1.3.2 Immuno-modulatory Activity
1.3.3 Anti-epileptic Activity
1.3.4 Anti-virus Activity
1.3.5 Antioxidative Activity
1.3.6 Other Activities
1.4 Conclusions
References of Chapter I
Ⅱ.Chemical Constituents of Cynanchum auriculatum
2.1 Introduction
2.2 Extraction, Isolation and Purification
2.3 Chemical Structures of Idetified Compounds
2.4 Structure Elucidation
2.4.1 New C21 Steroidal Glycosides
2.4.2 New Acetophenone
2.4.3 Known Compounds
2.5 Experimental Section
2.5.1 Plant Material
2.5.2 General Experimental Procedures
2.5.3 Acid Hydrolysis of Steroidal Glycosides
2.5.4 GC Analysis for Determination of Glucose Absolute Configuration
2.5.5 Physico-chemical Property and NMR Data
2.6 Discussion
2.6.1 The Characteristics of C21 Steroidal Glycosides from Cynanchum auriculatum
2.6.2 The Isolation and Purification Flowchart of C21 Steroidal Glycosides
References for Chapter Ⅱ
Ⅲ.Bioactivies of Cynanchum auriculatum
3.1 Introduction
3.1.1 The Traditional Use of Cynanchum auriculatum
3.1.2 The Strategy of Bioactivity Studies on Cynanchum auriculatum
3.2 Anti-tumor Constituents
3.2.1 Anti-tumor Activity of Extract and Fractions
3.2.2 Anti-tumor Activity of Steroidal Glycosides
3.2.3 Qualitative Structure-activity Relationship of Steroidal Glycosides'Anti-tumor Activity
3.2.4 Experimental Section
3.3 Neuroprotective Constituents
3.3.1 Neuroprotective Effect against Glutamate Excitotoxicity
3.3.2 Anti-Alzheimer's Aβ42-induced Toxicity in Drosophila melanogaster
3.3.3 Mechanism Investigation of Neuroprotective Constituent-Cynandione A
3.4 Gastroprotective Constituents
3.4.1 Introduction
3.4.2 Gastroprotective Activity of Extract and Fractions
3.4.3 Gastroprotective Activity of Acetophenones from Cynanchum auriculatum
3.5 Discussion
3.5.1 Anti-tumor Constituents
3.5.2 Neuroprotection Constituents
3.5.3 Gastroprotection Constituents
References for Chapter Ⅲ
Papers and Patents
Acknowledgements
