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首页> 外文学位 >The association of endogenous pineal hormone melatonin and mammographic breast density in postmenopausal women.
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The association of endogenous pineal hormone melatonin and mammographic breast density in postmenopausal women.

机译：绝经后妇女内源性松果激素褪黑激素与乳房X线照片的乳房密度的关系。

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摘要

Background. Mammographic breast density (MBD) is a widely recognized surrogate marker of breast cancer risk and serves as the main dependent variable in our study. Epidemiologic evidence indicates that risk factors shared by breast cancer and mammographic breast density are also factors related to endogenous pineal melatonin which serves as the main independent variable. Experimental studies have consistently demonstrated anticarcinogenic, antiproliferative, antioxidant, and immunostimulating properties of endogenous melatonin. In epidemiologic studies that have investigated the role of melatonin deficiency in the etiology of breast cancer results are not consistent. It has also been reported that women who take aspirin have a lower risk of developing breast cancer but study results vary markedly. Aspirin use serves as our main independent variable in our secondary study of aspirin use and mammographic breast density. Objectives. We examined whether mammographic breast density would be inversely related to nocturnal endogenous melatonin and in a secondary analysis whether inversely related to aspirin use. Design. We recruited 293 postmenopausal women with appointments for screening mammograms at a large western New York state radiological clinic from March 2005 through August 2005 to conduct our cross-sectional study. Screening mammograms were taken during clinic visits and mammographic breast density was measured from digitized images utilizing a validated computer-assisted method. The main metabolite of endogenous melatonin, 6-sulfatoxymelatonin, was measured by radioimmunoassay from overnight urine samples and creatinine-adjusted. Aspirin use and covariate data were collected from interviews, questionnaires, and anthropometric measures taken during clinic visits. Results. The mean age was 58 (SD 6.0), 30% had BMI (kg/m2) classified as obese, and 15% of the women were nulliparous. In a general linear model we observed a marginally significant trend (p 0.04) for categorical melatonin inversely related to percentage mammographic density adjusted for age, BMI, number of full-term pregnancies, and past use of combination hormone replacement therapy. Stratified analysis of aspirin use and non-use yielded a 10% reduction in percentage mammographic density among nulliparous women in the aspirin group (adjusted mean percent density 32.7, 95% CI: 29.9-3.61) compared to non-aspirin users (mean 43.4, 95% CI: 36.7-50.2). Conclusions. The results of this study suggest that nocturnal melatonin secretion may be associated with traditional breast cancer risk factors such as mammographic density, age, BMI, and parity. Aspirin use appeared to be related to lower breast density in postmenopausal women who are nulliparous. The potential to reduce breast cancer risk through lifestyle habits such as the use of aspirin or to minimize the influence of modern disruption of endogenous melatonin warrants further study.
机译：背景。乳腺钼靶X光检查（MBD）是公认的乳腺癌风险替代指标，是我们研究中的主要因变量。流行病学证据表明，乳腺癌和乳腺钼靶X光检查所共有的危险因素也是与内源性松果体褪黑激素有关的因素，后者是主要的独立变量。实验研究一直证明内源性褪黑素具有抗癌，抗增殖，抗氧化和免疫刺激的特性。在流行病学研究中，褪黑素缺乏在乳腺癌病因中的作用研究结果不一致。也有报道称服用阿司匹林的女性患乳腺癌的风险较低，但研究结果差异很大。在我们对阿司匹林使用和乳房X光检查的乳房密度的二次研究中，阿司匹林的使用是我们的主要独立变量。目标。我们检查了乳房X光检查的乳房密度是否与夜间内源性褪黑激素成反比，在次要分析中与阿司匹林的使用成反比。设计。我们从2005年3月至2005年8月在纽约州西部一家大型放射诊所招募了293名绝经后女性，以筛查乳房X线照片，以进行横断面研究。在临床就诊期间进行了乳房X线筛查，并使用经过验证的计算机辅助方法从数字化图像中测量了乳房X线摄影的乳房密度。内源性褪黑激素的主要代谢物6-巯基氧基褪黑素通过放射免疫法从过夜尿液样品中进行了肌酸酐测定，并进行了肌酐调整。阿司匹林的使用和协变量数据是通过访谈，问卷调查和在诊所就诊期间采取的人体测量学方法收集的。结果。平均年龄为58岁（SD 6.0），有30％的BMI（kg / m2）被归类为肥胖，而15％的妇女是未产妇。在一般的线性模型中，我们观察到分类褪黑素的边际显着趋势（p 0.04）与针对年龄，BMI，足月妊娠数和过去联合激素替代治疗的乳房X线照片密度百分比成反比。与非阿司匹林使用者相比，对阿司匹林使用和不使用进行的分层分析显示，阿司匹林组未生育妇女的乳房X线照片密度降低了10％（调整后的平均密度百分比为32.7，95％CI：29.9-3.61）。 95％CI：36.7-50.2）。结论。这项研究的结果表明，夜间褪黑激素的分泌可能与传统的乳腺癌危险因素有关，如乳房X线照片密度，年龄，BMI和胎次。服用阿司匹林似乎与绝经后绝经后妇女的乳房密度降低有关。通过使用阿司匹林等生活习惯降低乳腺癌风险的潜力或使现代内源性褪黑激素破坏的影响最小化的潜力值得进一步研究。

著录项

  • 作者

    Teter, Barbara Elizabeth.;

  • 作者单位

    State University of New York at Buffalo.;

  • 授予单位 State University of New York at Buffalo.;
  • 学科 Health Sciences Epidemiology.; Health Sciences Oncology.
  • 学位 Ph.D.
  • 年度 2007
  • 页码 189 p.
  • 总页数 189
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 肿瘤学;
  • 关键词

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