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Epidemiological associations of metabolic factors with cancer risk and cancer late effects.

机译：代谢因素与癌症风险和癌症晚期效应的流行病学关联。

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摘要

There is interest in developing our knowledge of modifiable cancer risk factors. The three studies in this dissertation investigate the role of metabolic factors at two points along the cancer control continuum: etiology and treatment late-effects.; The first two studies examined questions of cancer etiology. The first examined the hypotheses that the metabolic syndrome and physical inactivity are associated positively with incident colorectal cancer in a large prospective cohort of men and women. There was a dose-response association between colorectal cancer and the number of metabolic syndrome components present at baseline (Ptrend: 0.05) after multivariate adjustment. Metabolic syndrome (≥ 3 vs. 0 components) was associated positively with age- and gender-adjusted colorectal cancer (RR: 1.71 [95% CI: 1.1, 2.7]); this association was attenuated after multivariate adjustment (RR: 1.49 [0.9, 2.4]). The multivariate-adjusted association was strong in men (RR: 2.20 [1.1, 4.3]) and absent in women (RR: 1.01 [0.5, 2.0]). There was no association between physical activity and colorectal cancer (Sports Index Q4 vs. Q1 RR: 0.82 [0.5,1.2]).; The second study examined the hypothesis that a randomized 39-week strength-training intervention in 57 women would increase insulin-like growth factor binding-protein (IGFBP)-2 levels in the treatment versus control group. Further analyses examined cross-sectional and longitudinal associations between body fat, insulin, and IGF-axis proteins (IGF-I and IGFBPs-1, -2, and -3). No intervention effect was observed for IGFBP-2 levels over 15 or 39 weeks (2-sided regression: p = 0.97 and p = 0.91, respectively). Body fat and insulin were inversely associated with IGFBP-1 and -2, but were not associated with IGF-I and IGFBP-3, at baseline and over 39 weeks.; The third project examined cancer late-effects and examined the hypotheses that a randomized twice-weekly strength training intervention in 78 recent breast cancer survivors would not increase the incidence of lymphedema or its symptoms. Incidence of clinically diagnosed lymphedema between baseline and six-months was 6.4% and 5.9% in the treatment and control groups, respectively (p = 0.54). Self-report symptoms did not vary between the two groups at six months (p = 0.24). No participant experienced a change in arm circumference measures after the intervention.
机译：有兴趣发展我们对可调节的癌症危险因素的认识。本论文的三项研究探讨了代谢因子在癌症控制连续性过程中两个方面的作用：病因学和治疗后效应。前两项研究检查了癌症病因学问题。第一个研究假设了以下假设：在许多预期的男女队列中，代谢综合症和缺乏体育活动与大肠癌的发生呈正相关。多变量调整后，大肠癌和基线时代谢综合征成分的数量之间存在剂量反应关系（趋势：0.05）。代谢综合征（≥3 vs. 0成分）与年龄和性别校正后的结直肠癌呈正相关（RR：1.71 [95％CI：1.1，2.7]）；多元调整后，这种关联性减弱（RR：1.49 [0.9，2.4]）。多元调整的关联性在男性中很强（RR：2.20 [1.1，4.3]），而在女性中则没有（RR：1.01 [0.5，2.0]）。体力活动与大肠癌之间没有关联（体育指数Q4与Q1 RR：0.82 [0.5,1.2]）；第二项研究检验了以下假设：治疗组与对照组相比，对57名女性进行39周的随机强度训练干预会增加胰岛素样生长因子结合蛋白（IGFBP）-2的水平。进一步的分析检查了人体脂肪，胰岛素和IGF轴蛋白（IGF-1和IGFBPs-1，-2和-3）之间的横断面和纵向联系。在15或39周内未观察到IGFBP-2水平的干预作用（两面回归：分别为p = 0.97和p = 0.91）。在基线和超过39周时，体脂和胰岛素与IGFBP-1和-2呈负相关，但与IGF-1和IGFBP-3不相关。第三个项目检查了癌症的后效应，并检查了以下假设：每周对78位最近的乳腺癌幸存者进行每周两次的随机强度训练干预不会增加淋巴水肿或其症状的发生率。在治疗组和对照组中，基线和六个月之间临床诊断的淋巴水肿的发生率分别为6.4％和5.9％（p = 0.54）。两组在六个月时的自我报告症状没有变化（p = 0.24）。干预后，没有参与者的手臂围度改变。

著录项

  • 作者

    Ahmed-Saucedo, Rehana Leila.;

  • 作者单位

    University of Minnesota.;

  • 授予单位 University of Minnesota.;
  • 学科 Health Sciences Public Health.; Health Sciences Oncology.
  • 学位 Ph.D.
  • 年度 2006
  • 页码 173 p.
  • 总页数 173
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 预防医学、卫生学;肿瘤学;
  • 关键词

  • 入库时间 2022-08-17 11:40:21

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