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Soy protein consumption in diabetic nephropathy and coronary heart disease.

机译：糖尿病肾病和冠心病中大豆蛋白的摄入。

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摘要

Type 2 diabetes mellitus (DM) is a serious chronic disease that is reaching epidemic levels in many countries worldwide. DM is associated with a series of long-term cardiovascular complications, which contribute to a high death toll. Two major long-term cardiovascular complications are diabetic nephropathy (DN) and coronary heart disease (CHD). Type 2 diabetic patients not only have higher incidences of these two complications, but they also have a poorer prognostic when afflicted with them.; This thesis examined the impact of dietary protein quantity and type on several aspects of type 2 DM. The present work showed that soy protein consumption compared to casein, especially at higher protein intakes, prevented the typical increase in urinary albumin excretion (UAE) found in a diabetic mouse model of DN. It also promoted a reduction in UAE in male type 2 diabetic patients with DN. Moreover, soy protein consumption improved the blood lipid profile, by increasing HDL cholesterol and reducing the total-to-HDL and the LDL-to-HDL cholesterol ratios. Together, these findings suggest that soy protein consumption may reduce the risks for both DN and CHD. Low protein diets (12% energy), independently of protein type, were also shown to reduce UAE in diabetic mice.; In the diabetic mice, the intestinal adaptation associated with type 2 DM was shown to be caused by non-specific mechanisms. Also, glucose absorption was unaffected by long-term changes in dietary protein quantity. Finally, intestinal adaptation was unaffected by long-term consumption of soy protein.; In conclusion, changes in both dietary protein quantity and type (soy protein instead of animal protein) were shown to have a positive impact on the progression of DN, without adversely affecting intestinal adaptation. Soy protein consumption was also shown to positively affect risk factors of CHD in type 2 diabetic patients. Thus, the consumption of soy protein products may constitute an important dietary modification for type 2 diabetic patients. In particular, diets with soy protein at higher protein intakes (∼1.4 g/kg/d in human study) may provide a practical alternative to low protein diets, to overcome potential problems with dietary compliance and the risk of malnutrition.
机译：2型糖尿病（DM）是一种严重的慢性疾病，在世界许多国家/地区都已达到流行病的水平。糖尿病与一系列长期的心血管并发症相关，导致高死亡人数。两种主要的长期心血管并发症是糖尿病肾病（DN）和冠心病（CHD）。 2型糖尿病患者不仅这两种并发症的发生率较高，而且患病后的预后也较差。本文研究了膳食蛋白质的数量和类型对2型糖尿病的几个方面的影响。目前的研究表明，与酪蛋白相比，大豆蛋白的消耗，特别是在蛋白质摄入量更高的情况下，阻止了糖尿病性DN小鼠模型中尿白蛋白排泄（UAE）的典型增加。它还促进了男性2型糖尿病DN患者的UAE降低。此外，大豆蛋白的摄入通过增加HDL胆固醇和降低总胆固醇与HDL胆固醇和LDL与HDL胆固醇的比例，改善了血脂水平。总之，这些发现表明食用大豆蛋白可以降低DN和CHD的风险。低蛋白饮食（12％的能量），与蛋白类型无关，也显示可以减少糖尿病小鼠的阿联酋。在糖尿病小鼠中，显示与2型DM相关的肠道适应性是由非特异性机制引起的。同样，葡萄糖的吸收不受日粮蛋白质量长期变化的影响。最后，肠道适应不受长期食用大豆蛋白的影响。总之，膳食蛋白质数量和类型（大豆蛋白代替动物蛋白）的变化均显示出对DN的进展有积极影响，而对肠道适应性没有不利影响。大豆蛋白的摄入还显示出积极影响2型糖尿病患者冠心病的危险因素。因此，大豆蛋白产品的消费可能构成2型糖尿病患者重要的饮食习惯。尤其是，蛋白质摄入量较高（在人体研究中约为1.4 g / kg / d）的大豆蛋白饮食可能为低蛋白饮食提供一种实用的替代方法，以克服饮食合规性和营养不良风险的潜在问题。

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  • 作者

    Teixeira, Sandra Renata Pinto de Araujo.;

  • 作者单位

    University of Illinois at Urbana-Champaign.;

  • 授予单位 University of Illinois at Urbana-Champaign.;
  • 学科 Health Sciences Nutrition.
  • 学位 Ph.D.
  • 年度 2001
  • 页码 159 p.
  • 总页数 159
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 预防医学、卫生学;
  • 关键词

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