In order to find new antitubercular compounds, 5'-O-{[ (2-hydroxylbenzoyl) hydrazino] carbonyl | adenosine was designed and synthesized with adenosine and methyl salicylate as starting materias in an overall yield of 11.1%. Its structure was confirmed by IR,~1H NMR,~(13)C NMR and HR-MS.%@@ 结核病(Tuberculosis)是由结核分枝杆菌(Mycobacterium tuberculosis)引起的慢性传染病,目前仍然是人类单死因疾病最高的传染病.目前全世界约有三分之一的人口受到结核菌感染,每年新发病例800多万,死亡人数达200万[1].近年来,耐多药结核菌(MDR-TB)和HIV/AIDS病双重感染的急剧增加,使得结核病的控制越来越困难.因此,寻找新的结核药物作用靶点,研究开发新型抗结核药物已迫在眉睫.
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