Objective To investigate the clinical effect of Ziprasidone combined with rehabilitation nursing intervention in the treatment of schizophrenia. Methods Eighty two cases of patients with schizophrenia admitted to the Third Peo-ple's Hospital of Panzhihua City from April 2014 to April 2015 were selected as observed objects, they were divided into observation group and control group according to the visiting sequence. The control group was given Ziprasidone for treatment, on basis of which, the observation group was given rehabilitation nursing intervention. The clinical effica-cy, positive and negative syndrome scale (PANSS) and complications between the two groups were observed and com-pared. Results The total effective rate after treatment in observation group (92.68%) was higher than that of control group (73.17%), the difference was statistically significant (P< 0.05). The scores of positive symptoms, negative symp-toms, general symptoms and total scores of PANSS after treatment in the two groups [observation group: (10.5±5.2), (12.6±3.2), (33.2±8.2), (51.2±2.6) points; control group: (18.6±3.9), (15.8±3.1), (38.4±5.2), (61.3±1.9) points] were all lower than those before treatment [observation group: (25.5±6.3), (23.4±5.6), (42.3±5.1), (86.8±11.3) points; control group: (26.8±5.2), (24.6±2.3), (43.6±7.6), (87.2±5.6) points], the differences were all statistically significant (all P <0.05), and the scores of positive symptoms, negative symptoms, general symptoms and total scores of PANSS after treat-ment in the observation group were all lower than those of control group, the differences were all statistically significant (all P< 0.05). The incidence of complications in the observation group (7.32%) was lower than that of control group (17.07%), the difference was statistically significant (P<0.05). Conclusion In clinic, Ziprasidone combined with reha-bilitation nursing intervention in patients with schizophrenia has a significant effect, which is worthy of promotion and application.%目的：探讨齐拉西酮联合康复护理干预在精神分裂症疾病治疗中的临床效果。方法选取2014年4月~2015年4月攀枝花市第三人民医院收治的82例精神分裂症患者作为观察对象，按就诊先后顺序分为观察组与对照组。对照组予以齐拉西酮治疗，在此基础上，观察组给予康复护理干预措施。观察比较两组临床疗效、阳性与阴性症状量表(PANSS)评分及并发症发生情况。结果观察组治疗后总有效率(92.68%)显著高于对照组(73.17%)，差异有统计学意义(P<0.05)。两组治疗后PANSS阳性症状、阴性症状、一般症状评分及总分[观察组院(10.5±5.2)、(12.6±3.2)、(33.2±8.2)、(51.2±2.6)分；对照组院(18.6±3.9)、(15.8±3.1)、(38.4±5.2)、(61.3±1.9)分]均显著低于治疗前[观察组院(25.5±6.3)、(23.4±5.6)、(42.3±5.1)、(86.8±11.3)分；对照组院(26.8±5.2)、(24.6±2.3)、(43.6±7.6)、(87.2±5.6)分]，差异均有统计学意义(均P<0.05)，且观察组治疗后PANSS阳性症状、阴性症状、一般症状评分及总分均显著低于对照组，差异均有统计学意义(均P<0.05)。观察组并发症发生率(7.32%)显著低于对照组(17.07%)，差异有统计学意义(P<0.05)。结论在临床上对精神分裂症患者予以齐拉西酮联合康复护理干预疗效显著，值得大力推广应用。
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