Objective To observe the clinical effect of sufentanil and fentanyl in induction of general anesthesia. Methods 76 cases of patients with general anesthesia induction in our hospital from January 2011 to January 2013 were analysed.The sufentanil group(S group,38 cases)was given sufentanil.The fentanyl group(F group,38 cases)was given fentanyl.The arterial pressure (MAP),systolic blood pressure (SBP),diastolic blood pressure (DBP) and heart rate (HR) of before induction of anesthesia (T0),after induction (T1),1min after trachea intubation (T2),3 min after intubation (T3) were observed. Results MAP、SBP、DBP and HR of two groups were decreased significantly in period of time of T1、T2、T3 and T4.There was significant difference to compare with T0 periodf(P<0.05). MAP、SBP、DBP and HR of F group were significant difference in period of time of T1、T2、T3 and T4(P < 0.05). Conclusion Application of sufentanil anesthesia induction can more effectively maintain hemodynamics stable during tracheal intubation, its influence is less than fentanyl.%目的：观察在全麻诱导中使用舒芬太尼及芬太尼的临床疗效。方法分析我院自2011年1月~2013年1月收治的行全麻诱导的患者76例。舒芬太尼组（S组)38例，给予舒芬太尼1μg/kg；芬太尼组（F组)38例，给予芬太尼5μg/kg。观察麻醉诱导前（T0）、气管插管后1min（T1）、气管插管后5 min（T5）、气管插管后10 min（T10）时的动脉压（MAP）、收缩压（SBP）、舒张压（DBP）、心率（HR）。结果 S组与F组在T1、T5、T10时段相比，MAP、SBP、DBP、HR均显著降低，与T0时段比较，也显著下降，在统计学上具有显著性意义（P＜0.05）。F组在T1、T2、T3、T4时段，MAP、SBP、DBP、HR下降程度高于S组。结论应用舒芬太尼进行麻醉诱导能更有效维持气管插管期间血流动力学稳定，其影响小于芬太尼。
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