目的：研究麻杏二陈特禀咳颗粒用于镇咳、抗炎和祛痰的药理作用。方法分别采用氨水引咳、二甲苯致小鼠耳廓肿胀和气管酚红排泄方法对麻杏二陈特禀咳颗粒镇咳、抗炎和祛痰的药理作用进行研究。结果麻杏二陈特禀咳颗粒止咳作用显著，高（40 g∕kg）、中（20 g∕kg）、低（10 g∕kg）剂量均有药效（ P﹤0．05或 P﹤0．01），且高剂量作用优于阳性药；抗炎与祛痰的药理作用只在高剂量时有所体现（ P﹤0．05）。结论麻杏二陈特禀咳颗粒镇咳作用明显，有一定的抗炎和祛痰作用。%Objective To study the antitussive,anti-inflammatory and expectorant pharmacological effects of Maxing Erchen Tebingke Granules. Methods The antitussive,anti-inflammatory and expectorant effects of Maxing Erchen Tebingke Granules were studied by us-ing ammonia-induced cough,xylene-induced mice auricle swelling and tracheal phenol red excretion. Results The antitussive effect was significant,with high dose(40 g∕kg),medium dose(20 g∕kg)and low dose(10 g∕kg)all showing curative effect( P ﹤ 0. 05 or P ﹤ 0. 01),and the efficacy in the high dose group was better than that of the positive medicine;but the anti-inflammatory and ex-pectorant effect only worked in the high dose group( P ﹤ 0. 05). Conclusion Maxing Erchen Tebingke Granules has obvious antitus-sive effect and also has certain anti-inflammatory and expectorant effect.
展开▼
