目的 研究SOX2蛋白在结直肠癌中的表达及临床意义.方法 收集80例结直肠癌手术标本及20例正常的肠黏膜标本,采用免疫组化法检测SOX2蛋白在标本中的表达情况.结果 SOX2蛋白在正常肠黏膜中不表达,在结直肠癌中高表达,表达率为41.3％.SOX2表达水平与TNM分期、肿瘤浸润深度、淋巴结转移、组织学分化程度、Ki-67和p53基因表达水平均相关(P＜0.05).SOX2高表达组患者术后的5年生存率和无瘤生存率分别为39.4％和21.2％,低表达组患者分别为95.7％和83.0％,差异有统计学意义(P =0.000).结论 SOX2蛋白在正常结直肠黏膜组织中不表达,在结直肠癌组织中表达率高,并可作为预测结直肠癌转移和预后的生物学指标.%Objective To study the expression and clinical significance of SOX2 protein in colorectal cancer. Methods Im-munohistochemistry method was used to detect the expression of SOX2 protein in 80 colorectal cancer tissues and 20 normal bowel mu-cosa tissues. Results The SOX2 protein was not expressed in normal bowel mucosa, but it highly expressed in colorectal cancer,and the positive rate was 41. 3% . The expression of SOX2 was correlated with TNM staging,tumor infiltration depth,lymph node metastasis, the expression of Ki-67 and p53(P <0. 05). 5-year overall survival rate and disease-free survival rate of the highly expressed SOX2 group were 39.4% and 21. 2% , respectively; while in the lowly expressed SOX2 group were 95. 7% and 83% Respectively. There were significant differences between the two groups ( P = 0. 000 ) . Conclusion The SOX2 protein is not expressed in normal colorectal mucosal, but highly expressed in colorectal cancer tissues. Expression level of SOX2 protein is a useful marker for predicting the metastasis and prognosis of colorectal cancer.
展开▼
