Objective:To explore the diagnostic value of Plasma fibrinogen in Ovarian cancer.Method: From November 2012 to March 2014, The level of FIB,CA125 and HE4 from 100 cases female Patients was measured, and comprehensive analysised the indicators including FIB,CA125 and HE4 before and after treatment.Result:The CA125 and HE4 of ovarian cancer group was the highest,and there was consistency of diagnostic results among four kinds of disease;The levels of FIB was the highest (4.53±0.71)g/L in the Pelvic abscess,and the mean level of FIB in cancer Patients was also more than the standard one (4.37±0.42)g/L(t=9.36,P＜0.01)compared with the benign group; The difference of FIB values before and after treatment in Pelvic abscess group was statistically significant (t=4.60,P=0.001).The level of FIB in the improved Patients with ovarian cancer was normal(3.58±0.79)g/L,while that in those without improvement was still in non-normal level (4.57±0.79)g/L.Conclusion:FIB can be used as an important inticator in early detection of Ovarian cancer and the follow-up monitoring.%目的:探讨血浆纤维蛋白原(FIB)在卵巢恶性肿瘤中的诊断价值.方法:检测2012年11月-2014年3月在笔者所在医院确诊的100例女性患者的血浆FIB、血清CA125、HE4,综合分析患者治疗前后FIB、CA125和HE4等指标变化.结果:CA125和HE4在卵巢恶性肿瘤组分值最高,在四种疾病中的诊断结果具有一致性;FIB值水平在盆腔脓肿中最高(4.53±0.71)g/L,在恶性肿瘤组FIB均值也超过标准水平(4.37±0.42)g/L,与良性肿瘤组相比(t=9.36,P＜0.01);盆腔脓肿患者治疗前后FIB值差异有统计学意义(t=4.60,P=0.001);卵巢恶性肿瘤患者中,改善组患者FIB值降至正常水平(3.58±0.79)g/L,而未改善组FIB值则仍处于非正常水平(4.57±0.79)g/L.结论:FIB可作为恶性肿瘤早期检测及肿瘤术后随诊监测的重要指标.
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