本研究开发出一条以1H-咪唑-5-甲酸(1)为起始原料,经酯化、氨化、酰化、氨解环合和氯代反应合成出2-异丙基-4-氯-咪唑并[5,1-f][1,2,4]三嗪(6)的路线,并对合成中关键步骤反应条件进行了优化:酰化、环合和氯代,对各中间体及目标产物6进行了核磁表征,6的总收率为29.2％.该方法操作简便、反应条件温和、原料价廉易得,是合成咪唑并三嗪类的简便合成路线.%In this paper,a synthetic route of imidazo-triazine compounds with simple operations and mild reaction conditions was developed.4-chloro-2-isopropyl-imidazo [5,1-f] [1,2,4] triazine (6) was synthesized by esterification,acylation,amination cyclization and chlorination reaction.The synthesis use 1H-imidazole-5-carboxylic acid (1) as the starting material.The reaction conditions of the key steps including acylation,cyclization,and chlorination were optimized.The intermediates and the target product 6 were characterized by NMR,and the total yield of 6 was 29.2％.
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