微生物发酵法是目前生产L-赖氨酸最主要的方法.L-赖氨酸生物合成存在两个完全不同的途径:二氨基庚二酸途径和α氨基己二酸途径；分别由不同的酶进行调节,控制L-赖氨酸的合成.笔者概述了L-赖氨酸生产方法、生物合成途径以及合成中关键性酶的调节作用和国内外L-赖氨酸生产菌育种方法的研究进展.%Fermentation was the mainly used method of L-lysine production presently. There were two completely different biosynthesis pathways of L-lysine; heptanedioic acid pathway, and α-amino hexaned-ioic acid pathway. Different enzymes were used to regulate the two pathways and control the synthesis of L-lysine. In this paper, production methods of L-lysine, biosynthetic pathways as well as the regulations of the key enzymes, and the research evolution of the breeding of L-lysine hyper-producer were summarized at home and abroad.
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