目的 探讨宫颈微环境中细胞游离亚铁原卟啉(FH)检测在宫颈癌筛查中的应用价值.方法回顾性分析120例同时行FH、人类乳头瘤病毒(HPV)及病理检查者的病例资料.以病理检查结果作为诊断的金标准,通过计算FH检测与HPV检测技术在宫颈癌筛查中的灵敏度、特异度、准确度、阳性预测值、阴性预测值、阳性似然比、阴性似然比及AUC,比较两种检测方法对宫颈病变的检出率.结果 120例受检者中,FH检测:灵敏度为76.47%、特异度为78.26%、准确率为77.50%、阳性预测值为72.22%、阴性预测值为81.82%、阳性似然比为351.76%、阴性似然比为30.07%、AUC为0.774;HPV检测:灵敏度为70.59%、特异度为73.91%、准确率为72.50%、阳性预测值为66.67%、阴性预测值为77.27%、阳性似然比为270.59%、阴性似然比为39.79%、AUC为0.723.结论 FH检测的灵敏度与HPV检测相当,对宫颈癌的筛查有一定临床应用价值.%Objective To investigate clinical values of cells free ferrous protoporphyrin examination in the screening of cervical carcinoma.Methods A retrospective analysis of data from January 2016 to November 2017 with FH examination of 120 cases were proved by cervical pathological examination in Anhui Provincial Hospital.The pathol-ogy results as the gold standard for diagnosis,the sensitivity,specificity,positive predictive value,negative predictive val-ue,accuracy positive and negative likelihood ratio and AUC of FH detection,LCT detection and HPV detection were cal-culated in the screening of cervical cancer.Results 120 cases underwent FH detection,HPV detection and pathological examination,the sensitivity of FH test was 76.47%,specificity was 78.26%,accuracy was 77.50%,positive predictive value was 72.22%,negative predictive value was 81.82%,positive likelihood ratio was 351.76%,negative likelihood ratio was 30.07%,AUC was 0.774;HPV 70.59%specificity of sensitivity test results was 73.91% and accuracy rate was 72.50%,the positive predictive value was 66.67%and negative predictive value was 77.27%,the positive likeli-hood ratio was 270.59%,negative likelihood ratio was 39.79%,AUC was 0.723.Conclusions The sensitivity of FH examination is similar to that of LCT and high-risk HPV.It has certain clinical value in the screening of cervical carcinoma.
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