目的 探讨肿瘤坏死因子-α(TNF-α)与转化生长因子-β1(TGF-β1)和癌症相关性乏力的关系.方法 选择92例癌症伴有轻、中度乏力患者为观察组,92例健康体检者为对照组.采用流式细胞仪测定血清TNF-α、TGF-β1的含量.结果 治疗前,患者血清TNF-α为(27.35 ±12.08)ng/L,显著高于健康对照组的(12.04 ±5.44)ng/L(t=11.080,P<0.001).患者治疗后TNF-α明显降低为(18.57 ±10.32)ng/L(t=5.369, P<0.001).治疗前,患者血清TGF-β1为(39.26 ±10.65)ng/L,显著高于健康对照组的(16.53 ±6.37)ng/L (t=17.570,P<0.001).患者治疗后TGF-β1明显降低为(25.98 ±7.87)ng/L(t=8.952,P<0.001).结论癌症相关性乏力的发病机制可能由于血清TNF-α、TGF-β1等细胞因子的表达增强引起的.%Objective To investigate the relationship between cancer-related weakness and TNF-α and TGF-β1.Methods A total of 92 cancer patients with light and mediumly weak were enrolled in observation group,and 92 cases of healthy physical examination were enrolled in control group.The serum TNF-αand TGF-β1were detected by using flow cytometry.Results Before treatment,the serum TNF-αlevels of observation group was(27.35 ±12.08) ng/L,which was significantly higher than that of control group(12.04 ±5.44)ng/L(t=11.080,P<0.001).And af-ter treatment,the TNF-αof observation group reduced to(18.57 ±10.32)ng/L(t=5.369,P<0.001).Before treat-ment,the serum TNF-β1levels of observation group was(39.26 ±10.65)ng/L,which was significantly higher than that of control group(16.53 ±6.37)ng/L(t=17.570,P<0.001),which was reduced to(25.98 ±7.87)ng/L(t=8.952,P<0.001)after treatment.Conclusion The pathogenesis of cancer-related weakness may be due to the in-crease of serum TNF-αand TGF-β1.
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