目的研究非小细胞肺癌（NSCLC）患者表皮生长因子受体（EGFR）基因突变与血清癌胚抗原（CEA）、糖类抗原（CA125、CA199）的关系，研究其对靶向治疗的价值。方法选择非小细胞肺癌患者193例，术前行血清 CEA、CA125、CA199检测作为备用数据，术后对标本行 EGFR 检测，分析 CEA、CA125、CA199与EGFR基因突变的关系及临床意义。结果全组患者中发生 EGFR 基因突变者共83例，基因突变率为43．0％；EGFR 基因突变在女性、非吸烟及腺癌患者多见（P ＜0．05）；EGFR 基因突变与 CEA 值呈正相关（P ＜0．05）；EGFR与 CA125、CA199无相关性（P ＞0．05）。结论非小细胞肺癌 EGFR 基因突变在女性、非吸烟及腺癌患者中多见，其突变与血清 CEA 水平升高有关。%Objective To investigate the relationship between epidermal growth factor receptor (EGFR)gene mutation and carcino embryonie antigen (CEA),carbohydrate antigen (CA125,CA199)in patients with none small cell lung cancer (NSCLC)and explore prognostic values.Method 193 cases with NSCLC from January 2012 to January 2014 in the Laiwu People′s Hospital were selected,the preoperative serum levels of CEA,CA125,CA199 were detected and the relationship between the CEA,CA125,CA199 and EGFR gene mutation were analyzed.Result EGFR gene mutations were detected in 83 cases(43.0%);EGFR gene mutation were more commonly found in female,non-smokes and adenocarcinoma (P <0.05);EGFR gene mutation was positive correlated with CEA level(P <0.05);while there were no correlation between EGFR and CA125 /CA199(P >0.05).Conclusion EGFR gene mutation is more common-ly found in female,non-smokers and adenocarcinoma,which is related to the increased serum CEA level.
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