Objective To observed and analyze the changes of cognitive function in elderly patients with cere-bral vascular stenosis.Methods A total of 200 elderly patients with ischemic cerebral vascular disease were selected as research objects.The cerebral vascular stenosis,risk factors of cerebrovascular disease ,scores of mini-mentalstateexami-nation (MMSE)and incidence of cognitive dysfunction were observed and analyzed.Results The age,the rate of mer-ged diabetes,the rate of merged hypertension,the plasma homocysteine (Hcy),plasma fibrinogen,the serum total cho-lesterol of the patients with cerebral vascular stenosis were significantly higher than those ofthe patients without cerebral vascular stenosis (t =4.223,3.812,3.635,χ2 =33.734,9.814,all P <0.05 ).The MMSE score,immediate recall score,attention and calculationscore,delayed recall score of the patients with mild stenosis were significantly higher than those of patients with moderate stenosis or severe stenosis.The MMSE score and delayed recall score of the patients with moderate stenosis were significantly higher than those of patients with severe stenosis.The incidence of cognitive dys-function in the patients with severe stenosis was significantly higher than that in patients with moderate stenosis,and the incidence of cognitive dysfunction in patients with moderate stenosis was significantly higher than that in patients with mild stenosis (P <0.05).Logistic multivariate regression analysis showed that there were a statistical relation between age (OR =1.397),merged hypertension (OR =1.456),plasma Hcy level (OR =1.658)and degree of cerebral vascu-lar stenosis (OR =2.138)had a to cognitive dysfunction of patients (all P <0.05).Conclusions Cerebral vascular stenosis may be involved in the pathological processes of cognitive impairment,and can be used as an secondary indicati-or to predict the risk of cognitive dysfunction in the elderly patients.%目的：观察老年脑血管狭窄患者认知功能的改变，并分析影响因素。方法选取200例老年缺血性脑血管病患者作为研究对象，对其脑血管狭窄情况、脑血管病危险因素情况及存在脑血管狭窄患者的精神状态检查量表（MMSE）评分及认知功能障碍发生率进行观察和比较。结果有脑血管狭窄患者的年龄、合并高血压比例、合并糖尿病比例、血浆同型半胱氨酸（Hcy）水平、血浆纤维蛋白原水平、血清总胆固醇水平均显著高于无脑血管狭窄的患者（t ＝4．223、3．812、3．635，χ2＝33．734、9．814，均 P ＜0．05）；轻度狭窄患者的 MMSE 总分、即刻回忆力评分、注意计算力评分、延迟回忆力评分均显著高于中度狭窄患者或重度狭窄患者，中度狭窄患者的 MMSE 总分、延迟回忆力评分均显著高于重度狭窄患者，重度狭窄患者的认知功能障碍发生率显著高于中度狭窄患者，中度狭窄患者的认知功能障碍发生率显著高于轻度狭窄患者，差异均有统计学意义（P ＜0．05）；Logistic多元回归分析结果显示，患者发生认知功能障碍与年龄（OR ＝1．397）、合并高血压（OR ＝1．456）、血浆Hcy 水平（OR ＝1．658）和脑血管狭窄程度（OR ＝2．138）具有相关性（均 P ＜0．05）。结论脑血管狭窄可能参与了认知功能损害的病理过程，可作为预测患者认知功能障碍发生风险的辅助指标。
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