目的 比较多次皮下注射胰岛素与胰岛素泵强化治疗血糖控制欠佳的2型糖尿病(T2DM)患者的疗效.方法 观察对象分为胰岛素泵治疗组(CSⅡ组)40例和多次皮下胰岛素注射组(MSⅡ组)40例,CSⅡ组采用胰岛素泵持续皮下注射短效胰岛素,MSⅡ组采用三餐前皮下注射短效,夜间10点注射甘精胰岛素,应用剂量根据监测血糖来调整.比较两种治疗方法在控制血糖有效率、血糖达标时间、胰岛素均日用量及低血糖发生率等的不同.结果 两组降糖方案均有效,空腹血糖、餐后血糖均较治疗前明显下降,但CSⅡ组血糖达标时间、血糖的稳定性均优于MSⅡ组(P＜0.01),平均日胰岛素使用量低于MSⅡ组(P＜0.05),低血糖发生率无明显差别(P＞0.05).结论 胰岛素泵治疗的患者血糖可更快地较稳地达到预期目标,且安全性较好.%Objective To compare the efficacy of short term intensive therapy by insulin pump( CSⅡ) with multiple subcutaneous insulin injections (MSⅡ) in patients with poorly-controlled type 2 diabetes. Methods 100 pa-tients with poorly-controlled type 2 diabetes were divided into CSⅡ group and MSH group. CSⅡ group applied continuous subcutaneous Humulin R,MSⅡ group were injected Humulin R before three meals,and insulin glargine at 22:00. The dose of insulin were adjusted according to blood sugar. Results The treatment in two groups were all effective. Fasting blood glucose, postprandial blood sugar all were significantly lowered after treatment in both groups. CSⅡ group' s time needed for the same glycemia and the stability of the glucose were all better than MSⅡ group (P < 0. 01). At the same time,the dose of insulin of CSⅡ group was fewer than that of MSII group(P<0.05),hypoglycemia incidence showed no obvious difference between the two groups (P > 0.05). Conclusions Intensive therapy by insulin pump can control the hyperglycemia more effective and stable for patients with poorly-controlled type 2 diabetes.
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