Objective To evaluate the effect of rosuvastatin calcium on vasoactive substances , pulse pressure index ( PPI) and carotid artery intima-media thickness ( IMT) in patients with essential hypertension .Methods Eighty hyperten-sive patients were randomly divided into the observation group of 40 cases, with the antihypertensive drug and rosuvastatin cal-cium 10 mg orally 1 time a day, 40 patients in control group only received the antihypertensive drug .Before treatment,after 1 months, 6 months and 12months of treatment , 2 groups of patient’s high sensitivity C reactive protein (hs-CRP), homocys-teine(Hcy),blood pressure,pulse pressure index and intima media thickness were measured and recorded .Results No statis-tical significance differences of before treatment blood pressure , PPI, serum hs-CRP, Hcy and IMT were found between the 2 groups ( P >0.05).Compared with before treatment, after 1 months of treatment, brachial artery systolic blood pressure, PP in the 2 groups were significantly decreased ( P <0.05), and diastolic blood pressure did not change significantly;after 12 months of treatment, the PPI in control group revealed statistical significance differences ( P <0.05), after 1 months of treat-ment, the observation group’s PPI significantly reduced ( P <0.05).Compared with the control group, after 6 months of treatment, the observation group’s PP and systolic blood pressure decreased more significantly ( P <0.05), and treatment for 1, 6, 12 months later, compared with the same period control group , PPI in the observation group had significant differ-ence ( P <0.05).The observation group after treatment ,serum hs -CRP, Hcy concentration and IMT were significantly de-creased ( P <0.05),compared with the control group,the observation group’s hs-CRP had significant differences at the treat-ment of 1,6,12 months ( P <0.05);after treatment for 6,12 months,Hcy in the observation group had statistical significance difference ( P <0 K.05), treatment for 6 months, IMT also had significant difference ( P <0.05).Correlation analysis showed that PPI and serum hs-CRP, the concentration of Hcy and carotid artery IMT were positively correlated ( r =0.606, r = 0.583, r =0.672, P <0.05).Conclusion Rosuvastatin can significantly reduce the plasma vasoactive substances in hypertensive patients , improve IMT and reduce PPI , and thus inhibit the inflammatory reaction , reduce atherosclerotic plaque , improve blood vessel elasticity .%目的评价瑞舒伐他汀钙对高血压患者血管活性物质、脉压指数（PPI）及颈动脉内膜中层厚度（ IMT）的影响及相关性。方法选择高血压患者80例，随机分成观察组和对照组，每组各40例。观察组在原降压药物的基础上加服瑞舒伐他汀钙（10 mg/d），对照组则继续服用原降压药物不变，于治疗前及治疗1个月、6个月、12个月分别检测患者的血清高敏C反应蛋白（hs-CRP）、血同型半胱氨酸（Hcy）、血压、PPI及颈动脉IMT。结果2组治疗前血压、PPI、血清hs-CRP、Hcy及IMT比较差异无统计学意义（ P ＞0帋．05）。与治疗前相比，2组治疗1个月后肱动脉的收缩压、PP均有明显的降低（ P ＜0．05），而舒张压无显著改变；对照组PPI在治疗12个月后差异有统计学意义（P ＜0．05），观察组治疗1个月后PPI有明显的降低（ P ＜0．05）。与对照组相比，观察组治疗6个月后收缩压、PP降低更明显（ P ＜0．05），而PPI治疗1、6、12个月后与同期对照组相比差异均有统计学意义（ P ＜0．05）。观察组治疗后血清hs-CRP、Hcy浓度及IMT均有明显的降低（ P ＜0．05），与对照组相比，观察组hs-CRP治疗1、6、12个月后差异有统计学意义（ P ＜00．5）；Hcy治疗6、12个月后差异有统计学意义（ P ＜0．05），IMT治疗6个月后差异有统计学意义（ P ＜0．05）。相关性分析表明，PPI与血清hs-CRP、Hcy浓度及颈动脉IMT均呈正相关（分别为r ＝0．606、0．583、0．672， P ＜0．05）。结论瑞舒伐他汀能显著降低高血压患者血管活性物质水平，改善IMT并降低PPI，从而起到抑制炎性反应、缩小动脉粥样硬化斑块，改善血管弹性的作用。
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