AIM: Secretogranin Ⅲ ( SCG3/Sg Ⅲ ) is extensively distributed in endocrine or endocrine - like cells in human body and plays an important role in some biological functions by regulating peptide hormone secretion and neuroendocrine activity.The distribution and functions of SCG3 make itself as not only one of the most useful biological markers in association with neuroendocrine functions, but also a potential indicator of diagnostic and prognostic evaluation in certain diseases.The gene and protein structures, tissue expression, biological functions as well as pathophysiology and clinical significance of SCG3 are reviewed in this article.%@@ 分泌粒蛋白Ⅲ（secretogranin III,SCG3/Sg III）是粒蛋白家族（granin family）中一个较新的成员.该蛋白与粒蛋白家族其它成员一样,在分泌颗粒（secretory granules）的基质中表达丰富,为亲水性酸性蛋白质,带有丰富的电荷,广泛分布于神经内分泌细胞、内分泌细胞及神经细胞.
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