血管平滑肌细胞(VSMCs)表型改变、增殖、迁移、钙化等生物学活动的改变在动脉粥样硬化(AS)发生发展过程中具有重要作用.流行病学以及体内外实验研究表明,牙周炎与AS之间关系密切.而牙龈卟啉单胞菌(P.gingivalis)作为慢性牙周炎的主要致病菌之一,能侵入VSMCs,并通过改变细胞结构,促进增殖和迁移,促进多种炎性因子的分泌、钙化等,参与AS的形成与发展.文章主要从P.gingivalis对VSMCs各生物学活动的影响进展做一综述,以期进一步揭示牙周疾病与AS之间的关联,为两者之间关系的研究提供一定思路.%Phenotypic alteration,proliferation,migration,calcification and other biological activity changes may occur in vascular smooth muscle cells,which have an important impact on the development of atherosclerosis (AS).Epidemiological surveys and experiments in vivo and in vitro have demonstrated that periodontitis is closely related to AS.Porphyromonas gingivalis (P·gingivalis) is recognized as one of the major pathogens of chronic periodontitis.The P ·gingivalis promotes atherosclerosis formation by way of penetrating through the interior of the cells,changing the structure of cells,stimulating proliferation and migration,and promoting inflammatory cytokines secretion and calcification.This article reviews the biological activities of VSMCs influenced by P·gingivalis in order to reveal the connection between periodontitis and atherosclerosis and provide some ideas for researches.
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