Objective To investigate the effect of midazolam on cardiopulmonary function during colonoscopy.Methods From June 2014 to June 2015,214 patients underwent colonoscopy were randomly divided into two groups:109 patients in the midazolam group and 105 patients in the non-sedated group(control group).systolic blood pressure(SBP),diastolic blood pressure (DBP),heart rate (HR) and peripheral blood oxygen partial pressure (SpO2) in the two groups before and after colonoscopy were compared.Results In the midazolam group,SBP and DBP decreased more during colonoscopy than in the control group.However,the frequency with a significant change in SBP was similar in both groups.During colonoscopy,HR andSpO2 decreased more in the midazolam group compared to those in the control group.SpO2 levels returned to normal after the procedure in two groups.Conclusion Midazolam has a tolerable effect on cardiopulmonary function and may be safely used during colonoscopy.%目的 探讨咪达唑仑在结肠镜检查清醒镇静中对心肺功能的影响.方法 2014年6月至2015年6月,连续纳入在临沂市沂水中心医院行结肠镜检查患者214例,根据镇静状态分为2组:咪达唑仑组109例和非镇静组105例(对照组).观察记录并对比分析两组患者在结肠镜检查前、检查过程中及检查结束后收缩压(SBP)、舒张压(DBP)、心率(HR)及外周血氧分压(SpO2)的变化.结果 结肠镜检查过程中,咪达唑仑组患者的SBP和DBP下降较对照组更明显,但两组患者SBP显著变化的发生率相当;咪迭唑仑组患者的HR和SpO2下降较对照组更明显;两组患者检查结束后SpO2均恢复正常.结论 在结肠镜检查过程中,咪达唑仑对患者心肺功能影响较小,可安全地应用于结肠镜检查的清醒镇静中.
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