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首页> 外文期刊>Digestive endoscopy: official journal of the Japan Gastroenterological Endoscopy Society >Effect of midazolam on cardiopulmonary function during colonoscopy with conscious sedation
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Effect of midazolam on cardiopulmonary function during colonoscopy with conscious sedation

机译：咪唑安定对清醒镇静的结肠镜检查期间心肺功能的影响

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Background and Aim Conscious sedation of patients with midazolam reduces anxiety and pain and improves colonoscopy success rates. However, it may lead to adverse effects such as hypoxia and hypotension. The present study investigated the effects of midazolam on cardiopulmonary function during colonoscopy with conscious sedation. Methods Between January 2011 and September 2011, 126 consecutive patients undergoing colonoscopy were enrolled and divided into two groups: (i) sedation with midazolam (midazolam group, n=65); and (ii) no sedation (control group, n=61). Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), and peripheral oxygen saturation (SpO 2), were recorded before, during and after the endoscopic procedure. Results In the midazolam group, SBP and DBP decreased more during colonoscopy than in the control group. However, the frequency of a significant change in SBP was similar in both groups. During colonoscopy, HR and SpO2 decreased significantly in the midazolam group compared to those in the control group. SpO2 levels returned to normal after the procedure. Conclusions Midazolam induced decreases in SBP, DBP, HR and SpO2 during colonoscopy. Clinically significant changes in SBP, HR, and SpO 2, however, were similar in the midazolam and control groups. These results suggest that midazolam has a tolerable effect on cardiopulmonary function and may be safely used during colonoscopy.
机译：背景和目的咪达唑仑镇静患者的镇静作用可减轻焦虑和疼痛，并提高结肠镜检查的成功率。但是，它可能导致诸如缺氧和低血压等不良反应。本研究调查了咪唑安定对结肠镜检查中有意识的镇静作用对心肺功能的影响。方法选择2011年1月至2011年9月连续126例行结肠镜检查的患者，分为两组。 （ii）无镇静作用（对照组，n = 61）。在内窥镜检查之前，期间和之后记录收缩压（SBP），舒张压（DBP），心率（HR）和外周血氧饱和度（SpO 2）。结果在咪达唑仑组中，结肠镜检查时SBP和DBP的下降比对照组大。但是，两组的SBP显着变化的频率相似。在结肠镜检查期间，与对照组相比，咪达唑仑组的HR和SpO2明显降低。手术后SpO2水平恢复正常。结论咪达唑仑在结肠镜检查期间引起SBP，DBP，HR和SpO2降低。然而，咪达唑仑和对照组的SBP，HR和SpO 2的临床显着变化相似。这些结果表明，咪达唑仑对心肺功能具有可耐受的作用，可在结肠镜检查期间安全使用。

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