OBJECTIVE: To probe into the effects of sophora flavescens combined with conventional treatment on the immune function in patients with chronic hepatitis B .METHODS: 92 patients with chronic hepatitis B admitted into Ganzhou Nankang District Hospital of Traditional Chinese Medicine from Jan .2015 to Jun.2017 were according to admission order grouping,single number as the observation group,double number as the control group, with 46 cases in each.The control group was given conventional treatment, while the observation group additionally received sophora flavescens based on the control group; the treatment course was 6 months.The improvement of symptoms, hepatitis B virus (HBV) DNA and HBeAg, content of serum HBV DNA,levels of CD3 +, CD4 +, CD8 +and CD4 +/CD8 +of two groups were observed.RESULTS:After treatment, the clinical symptoms and signs of two groups had been improved compared with before treatment , and the observation group was significantly lower than the control group.The negative conversion ratio of HBV DNA and HBeAg of observation group were respectively 93.48％ (43/46) and 86.96％ (40/46), significantly higher than that of control group [60.87％ (28/46) and 54.35％ (25/46)]; the content of serum HBV DNA of observation group was (9.01 ±0.44) ×102 copy/ml, significantly better than that of control group [(8.85 ±0.55) ×104 copy/ml];the levels of CD3 +, CD4 +, CD8 +and CD4 +/CD8 +of two groups were significantly better than those of before treatment , and the observation group was better than the control group, with statistically significant differences( P<0.05) .CONCLUSIONS:The effects of sophora flavescens combined with conventional treatment for patients with chronic hepatitis B is significant , which can inhibit the replication activity of hepatitis B virus, improve patients' immune function, and help to alleviate its clinical manifestations.%目的:探讨苦参制剂联合常规治疗对慢性乙型肝炎患者免疫功能的影响.方法:选取2015年1月—2017年6月赣州市南康区中医院收治的慢性乙型肝炎患者92例,按照入院顺序分组,单号为观察组,双号为对照组,每组46例.对照组患者给予常规治疗,观察组患者在对照组基础上加用苦参制剂,两组患者均持续治疗6个月.观察两组患者症状体征改善情况,乙型肝炎病毒(hepatitis B virus,HBV)DNA和HBV E抗原(HBeAg)转阴情况,血清HBV DNA含量,CD3+、CD4+、CD8+及CD4+/CD8+水平.结果:治疗后,两组患者各症状体征积分均较治疗前明显降低,且观察组患者明显低于对照组;观察组患者HBV DNA、HBeAg转阴率分别为93.48％(43/46)、86.96％(40/46),明显高于对照组的60.87％(28/46)、54.35％(25/46);观察组患者平均血清HBV DNA含量为(9.01±0.44)×102 copy/ml,明显低于对照组的(8.85±0.55)×104 copy/ml;两组患者CD3+、CD4+、CD8+及CD4+/CD8+水平明显优于治疗前,且观察组患者明显优于对照组,上述差异均有统计学意义(P<0.05).结论:苦参制剂联合常规治疗治疗慢性乙型肝炎的效果较好,可抑制HBV活性,改善患者免疫功能,缓解患者临床症状.
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