The development situation of lycopene produced with natural product extraction, chemical synthesis and microbial fermentation were reviewed. And based on comparative analysis of three production methods of lycopene, the development prospects of microbial fermentation production of lycopene were looked ahead.% 综述天然产物提取法、化学合成法、微生物发酵法生产番茄红素的发展现状，并在对番茄红素三种生产方法比较分析的基础上，展望了微生物发酵法生产番茄红素的发展前景。
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