Proanthocyanidins is a collective name of a class of polyphenolic compounds widely found in the plant kingdom, of which the richest content is the grape seed. The research shows that GSPE has the pathological functions like scavenging free radicals, antioxidation, antitumor, anti atherosclerosis and resistance to radiation and therapeutical functions to diseases of many systems. As a natural antioxidant. GSPE conforms to modern people’s demand for high efficient and low-toxicity drugs, which has wide devel-opment prospects. This essay makes a review of the research advances of GSPE in Cardiovascular system diseases, cancer, and male reproductive system diseases and eye disease and discusses its mechanisms re-lated to resisting oxidation and free radicals so that it can provide reference for its further development and utilization.%原花青素是一类广泛存在于植物界的多酚化合物的总称，其中以葡萄籽的含量最为丰富。研究表明，葡萄籽原花青素具有清除自由基、抗氧化、抗肿瘤、抗动脉粥样硬化、抗辐射等药理作用，对多个系统的疾病具有一定的治疗作用。作为一种天然抗氧化剂，葡萄籽原花青素符合现代人们对高效、低毒药物的需求，具有广阔的开发前景。本文就葡萄籽原花青素在心血管系统疾病、癌症、男性生殖系统疾病、眼科疾病等方面的研究进展进行综述，并讨论了其与抗氧化和清除自由基能力相关的作用机制，为葡萄籽原花青素的进一步开发和利用提供参考。
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