目的：探讨生长抑素对急性胰腺炎（ acute pancreatitis ，AP）患者血小板相关指标及胃肠动力的影响。方法将106例AP患者随机分为治疗组和对照组各53例。所有患者均给予胃肠减压、禁食、抗感染、补液等支持治疗，治疗组于发病24 h内给予6 mg／d生长抑素，连用7 d。检测两组患者血小板相关指标的变化，记录两组患者的胃肠动力及预后情况。结果与对照组比较，治疗组治疗后3 d、7 d血小板分布宽度（ platelet distribution width ，PDW）显著降低，血小板计数（platelets，PLT）、血小板容积比（PCT）均显著升高（P＜0．05）；治疗组恶心呕吐缓解时间、腹胀缓解时间、血淀粉酶恢复时间均显著缩短，胃管日均引流量显著减少，平均住院时间显著缩短，中转手术率显著下降（均P＜0．05）。与死亡组比较，存活组患者平均血小板体积（mean platelet volume，MPV）和PDW显著降低， PLT、PCT均显著升高（ P＜0．05）。结论 AP患者早期应用生长抑素，可有效调节血小板活性，改善胰腺微循环与胃肠动力，改善预后。%Objective To explore the effect of somatostatin on platelet-related indicators and gastrointestinal motility of patients with acute pancreatitis (AP).Method 106 cases of APwere randomly divided into two groups.All patients were firstly treated with gastrointestinal decompression , fasting, fight infection, and rehydration support treatment . The experimental group was the given somatostatin 6 mg/d for 7 days in a row .The change in platelet-related indicators of the two groups was monitored and the gastrointestinal dysmotility and prognosis of both groups were recorded .Findings Compared with the control group, the experimental group at 3rd, 7th day after treatment had significantly lowered platelet distribution width (PDW) and higher platelets (PLT) and PCT (P<0.05).The ease time of nausea and vomiting, abdominal distension , recovery time of blood amylase of the experimental group were significantly shortened .The fluid volume of stomach tube per day decreased significantly in the experimental group (P<0.05).Compared with the death group, the survival group had significantly lowered PDW , mean platelet volume ( MPV), and higher PLT, PCT ( P <0.05).Conclusion Somatostatin for APat early time can effectively regulate platelet activity , improve the pancreatic microcirculation and gastrointestinal motility and thus improve prognosis .
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