Objective To observe the therapeutic effects of labetalol combined with magnesium sulfate on early onset severe preeclampsia and its effects on pregnancy outcome. Methods A total of 126 patients with early onset severe preeclampsia who were admitted and treated in our hospital from August 2012 to October 2016 were enrolled in the study. According to random number table,these patients were divided into control group and observation group,with 63 patients in each group.The patients in control group were treated by magnesium sulfate,however,the patients in observation group were treated by leberolol combined with magnesium sulfate. The blood pressure,coagulation and fibrinolysis indexes,the time of termination of pregnancy,the mode of delivery,Apgar score and adverse reactions of neonates were observed and compared between two groups. Results As compared with those before treatment,the systolic pressure and diastolic pressure were significantly decreased in both groups (P<0.05),moreover,which in observation group were significantly lower than those in control group (P<0.05).As compared with those before treatment,the levels of PT and APPT were significantly increased in both groups,however,the levels of Fg and DD were significantly decreased (P<0.05),moreover,the levels of PT and APPT in observation group were significantly higher than those in control group,and the levels of Fg and DD were significantly lower than those in control group(P<0.05).However there was no significant difference in delivery mode between two groups(P>0.05). Moreover the gestation time in observation group was significantly longer than that in control group,and Apgar scores of neonates were significantly higher than those in control group (P <0.05). As compared with those in control group,the incidence rates of mild palpitations,transient hypotension,blood pressure quick decrease were significantly decreased in observation group.In addition the incidence rate of adverse reactions in observation group was significantly lower than that in control group (P<0.05).Conclusion The labetalol combined with magnesium sulfate in treatment of early onset of severe preeclampsia has better curative effects,without increasing the risk of adverse reactions,which can improve blood rheological characteristics,which is beneficial to control maternal disease condition,improve pregnancy outcomes,therefor,which is worth using widely in clinical practice.%目的 拉贝洛尔结合硫酸镁治疗对早发型重度子痫前期患者的疗效及对妊娠结局的影响.方法 选取2012年8月至2016年10月收入的126例早发型重度子痫前期的孕妇,根据随机数字表法分为对照组63例,观察组63例.对照组患者接受硫酸镁治疗,而观察组患者以拉贝洛尔结合硫酸镁进行治疗,对2组患者的血压、凝血与纤溶指标、妊娠终止时间、分娩方式及新生儿Apgar评分及不良反应.结果 与治疗前比较,2组患者收缩压及舒张压均出现了明显降低,差异有统计学意义(P<0.05).与对照组比较,观察组治疗后收缩压、舒张压均明显降低,差异有统计学意义(t=5.643、6.237,P<0.05).与治疗前比较,2组患者PT、APPT水平明显更高,Fg及DD水平均出现了明显降低,差异有统计学意义(P<0.05).与对照组比较,观察组治疗后PT、APPT水平明显更高,Fg及DD水平均明显降低,差异有统计学意义(t=6.719、6.576、14.418、4.235,P<0.05).与对照组比较,观察组分娩方式差异无统计学意义(χ2=1.143,P>0.05),妊娠时间明显更长,新生儿Apgar评分>7的明显更多,差异有统计学意义(t=8.664, χ2=6.013,P<0.05).与对照组比较,观察组患者出现轻度心悸、一过性低血压、血压下降过快的人数明显更低,不良反应发生率更低,差异有统计学意义(Z=7.443,P<0.05).结论 拉贝洛尔结合硫酸镁治疗对早发型重度子痫前期患者的疗效较好,其不良风险无明显上升,能改善血液流变性,对于控制产妇病情,改善妊娠结局,减少不良妊娠结局风险较为有利,值得在临床上推广运用.
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