目的 探讨慢性心力衰竭与白细胞介素(IL)-17、IL-10的相关性.方法 采用酶联免疫吸附试验(ELISA)检测37例慢性心力衰竭患者(慢性心衰组)和34例健康体检者(对照组)血浆IL-17和IL-10水平,并进行相关性分析.结果 慢性心衰组血浆IL-17水平高于对照组[(46.37±10.57) ng/L vs(32.45±4.55)ng/L],IL-10水平低于对照组[(27.49±4.19) ng/L vs(32.71±4.38) ng/L],差异均有统计学意义(t=7.09,5.46,P＜0.01);慢性心力衰竭患者血浆IL-17与IL-10呈负相关(r=-0.63,P＜0.01).结论 慢性心力衰竭的发病可能与体内IL-17、IL-10的水平失衡存在相关.%Objective To investigate the correlation between chronic heart failure and the levels of IL-17 and IL-10.Methods The levels of IL-17 and IL-10 was measured by enzyme-linked immunosorbent assay (ELISA) in 37 patients with chronic heart failure (chronic heart failure group) and 34 normal controls(control group).The correlation between chronic heart failure and the levels of IL-17 and IL-10.Results The level of IL-17 was higher and the level of IL-10 was lower in the chronic heart failure group than that in the control group[(46.37±10.57)ng/L vs.(32.45±4.55) ng/L,t=7.09,P＜0.01;(27.49±4.19)ng/L vs.(32.71±4.38)ng/L,t=5.46,P＜0.01],with statistical differences.There was negative correlation between IL-17 and IL-10 in patients with chronic heart failure (r=-0.63.P＜0.01).Conclusions The pathogenesis of chronic heart failure may relate to the imbalance of IL-17and IL-10.
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