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首页> 外文期刊>Allergy and asthma proceedings >Serum interleukin 17, interleukin 23, and interleukin 10 values in children with atopic eczema/dermatitis syndrome (AEDS): Association with clinical severity and phenotype
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Serum interleukin 17, interleukin 23, and interleukin 10 values in children with atopic eczema/dermatitis syndrome (AEDS): Association with clinical severity and phenotype

机译：特应性湿疹/皮炎综合征（AEDS）儿童的血清白细胞介素17，白细胞介素23和白细胞介素10值：与临床严重程度和表型的关系

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摘要

To date cytokines profile in AEDS is poorly described in children. We evaluated the interleukin (IL)-17, IL-23, and IL-10 levels in atopic eczema/dermatitis syndrome (AEDS) children and healthy controls, in atopic AEDS (aAEDS) and nonatopic (naAEDS) subtypes and their relationship with disease severity. A total of 181 children with aAEDS and 93 healthy children were evaluated. According to the skin-prick test (SPT) for allergens and serum total IgE, all patients were subdivided in two groups: 104 aAEDS and 77 naAEDS. In all patients, serum IL-17, IL-23, and IL-10 levels were detected. Serum IL-17 and IL-23 levels were significantly higher, and serum IL-10 levels were significantly lower in AEDS children than healthy group (p < 0.001). Moreover, serum IL-17 and IL-23 levels were significantly higher in aAEDS than in naAEDS subtypes (p < 0.001). Differently, serum IL-10 levels resulted similar in both subtypes. There was a correlation between Score Atopic Dermatitis (SCORAD) index and both IL-17 and IL-23 and an inverse correlation between SCORAD index and IL-10 in aAEDS and naAEDS types. Serum IL-17 and IL-23 values were positively related to total IgE levels (p < 0.0001) in aAEDS. Further increase of IL-17 and IL-23 levels was detected in aAEDS subjects with atopic diseases such as asthma and rhinitis than children with only allergic sensitization. Our study confirms the role of IL-17, IL-23, and IL-10 and their relationship with the severity of AEDS. We firstly found a correlation between high IL-17/IL-23 axis levels and different phenotypes of AEDS in children, suggesting its role as marker of "atopic march" and disease severity.
机译：迄今为止，在儿童中AEDS中的细胞因子谱描述很少。我们评估了特应性AEDS（aAEDS）和非特应性（naAEDS）亚型的特应性湿疹/皮炎综合征（AEDS）儿童和健康对照组中的白介素（IL）-17，IL-23和IL-10水平，以及它们与疾病的关系严重性。总共评估了181名患有aAEDS的儿童和93名健康儿童。根据针对皮肤过敏原和血清总IgE的皮肤点刺试验（SPT），将所有患者分为104组aAEDS和77组naAEDS。在所有患者中，均检测到血清IL-17，IL-23和IL-10水平。 AEDS患儿的血清IL-17和IL-23水平显着升高，血清IL-10水平显着低于健康组（P <0.001）。此外，aAEDS中的血清IL-17和IL-23水平明显高于naAEDS亚型（p <0.001）。不同的是，两种亚型的血清IL-10水平相似。在aAEDS和naAEDS类型中，特应性皮炎评分（SCORAD）指数与IL-17和IL-23呈负相关，而SCORAD指数与IL-10呈负相关。在aAEDS中，血清IL-17和IL-23值与总IgE水平呈正相关（p <0.0001）。与患有过敏性疾病的儿童相比，患有特应性疾病（例如哮喘和鼻炎）的aAEDS受试者中检测到的IL-17和IL-23水平进一步升高。我们的研究证实了IL-17，IL-23和IL-10的作用及其与AEDS严重程度的关系。我们首先发现高IL-17 / IL-23轴水平与儿童AEDS的不同表型之间存在相关性，表明其作为“特应性行军”标志物和疾病严重程度的作用。

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