目的 评价深度水解蛋白配方奶配合早期微量喂养在极低出生体重儿营养支持中的临床应用效果.方法 选取2013年1月至2014年11月出生12小时内人住惠东县妇幼保健院新生儿科的极低出生体重儿90例,按抽签法随机分为A、B、C组.A组:12小时内给予深度水解蛋白配方奶(eHF)微量喂养,14天后改等量的早产儿配方奶(SPF)继续喂养;B组:12小时内给予SPF微量喂养;C组:为对照组,给予常规治疗,12小时以后开始SPF喂养.比较三组患儿恢复出生体重的日龄、喂养不耐受的发生率及新生儿贫血、宫外发育迟缓和NEC的发生率.结果 恢复出生体重时间A组短于B、C组,喂养不耐受发生率A组低于B组、C组,差异均有统计学意义;三组喂养方式下,A组新生儿贫血、宫外发育迟缓和NEC发生率低于B组和C组.结论 深度水解蛋白配方奶配合早期微量喂养可促进极低出生体重儿体重的早期恢复,改善喂养不耐受的发生率.%Objective To evaluate the clinical efficacy of minimal enteral feeding of extensively hydrolyzed infant formula in nutritional support for very low birth weight infants.Methods 90 very low birth weight infants born within 12 hours and admitted into Department of Neonates,Huidong Children and Maternal Hospital from January 2013,to November,2014 were selected and were randomly divided into group A,group B,and group C according to lottery method.Group A were minimally fed with extensively hydrolyzed infant formula (eHF) within 12 hours,14 days from then with the same amount of standard preterm infant formula (SPF);group B with SPF within 12 hours;and group C (a control group) conventionally treated and with SPF 12 hours after being admitted.The time recovering to birth weight and the incidences of feeding intolerance,anemia,extra uterine growth restriction (EUGR),and necrotizing enterocolitis (NEC).Results The time recovering to birth weight was significantly shorter and the incidence of feeding intolerance was lower in group A than in group B and group C,with statistical differences.The incidences of anemia,EUGR,and NEC were lower in group A than in group B and group C.Conclusions Minimal enteral feeding of extensively hydrolyzed infant formula with can recover very low birth weight infants' weight early and decrease the incidence of feeding intolerance.
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