[目的]对蓖麻油进行微胶囊化,制成蓖麻油缓释微胶囊.[方法]运用复凝聚法,以明胶和阿拉伯胶为囊材,蓖麻油为囊心物制备微囊.借助显微镜观察微囊形态;通过紫外分光光度计进行蓖麻油含量测定;以水为溶出介质考察该制剂的体外溶出情况;以包封率作为质量判定指标,采用单因素考察和正交试验优化处方工艺.[结果]蓖麻油缓释微囊的最佳制备工艺条件为:明胶和阿拉伯胶浓度皆为7.5%,甲醛用量为1.0 ml,pH值为3.80,材药比为6:1.按该处方制得的微囊囊型圆整光滑,载药量较高,并具有一定的缓释效果.[结论]复凝聚法可成功制备出包封率较高的蓖麻油缓释微囊,且产品稳定性良好.该法可操作性强,重复性好,有一定的实用价值.%[ Objective ] Microencapsulation was carried out for castor oil, thus, sustained-release castor oil microcapsule was prepared. [ Method ]Complex coacervation method was used, and taking gelatin and Arabic gum as capsule materials, in addition, castor oil was viewed as core materials to prepare micro-capsule. The shapes of microcapsules were observed with the help of microscope, the content of castor oil was determined based on ultraviolet spectrophotometer; and dissolution rate in vitro with water were investigated. With encapsulation efficiency as quahty evaluation index, furthermore, the prescription was optimized by single phoneme and orthogonal experiment. [ Result ] The best preparation technological conditions of sustained-release castor oil microcapsule were：the gelatin and the Arabic gum density was 7.5％, the formaldehyde amount was the 1.0 ml, pH value was 3.80, the proportion of raw material to medicine was 6∶1. According to this prescription, the shape of micro-capsule was rounding and smooth, and showed larger loading capacity, moreover, had certain sustained-release effect. [ Conclusion ] The duplicate condensation law may successfully prepared sustained-release castor oil microcapsule with higher entrapment rate, moreover, the product stability was good. The method had strong operability and good duplication, thus, had certain practical value.
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