Study on the relationship of cytochrome C expression and cerebral edema in perihematomal brain tissue in patients with hypertensive cerebral hemorrhage

CAI Heng; LIU Guixiang; XU Chunsheng; LIU Qingxin; XU Xiaobo

首页> 中文期刊> 《滨州医学院学报》 >Study on the relationship of cytochrome C expression and cerebral edema in perihematomal brain tissue in patients with hypertensive cerebral hemorrhage

Study on the relationship of cytochrome C expression and cerebral edema in perihematomal brain tissue in patients with hypertensive cerebral hemorrhage

开具论文收录证明 >>

期刊封面封底目录下载 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Objective To investigate the expression of cytochrome C in perihematomal brain tissue and its relationship with the histopathological change and formation of cerebral edema in patients with hypertensive cerebral hemorrhage. Methods Thirty four patients (23 male, 11 female) of hypertensive cerebral hemorrhage in hospital from Sep. 2001 to Sep. 2002 were selected with a mean age 55.6± 10.2 years (from 35 to 75 years). The mean volume of hemorrhagic blood was 50.4±11.6 ml (from 25 to 85 ml). The perihematomal brain tissue was obtained from the minimally invasive surgery. Histopathological change and expressions of cytochrome C in perihematomal brain tissue was detected by histopathological and immunohistochemical techniques. The volume of perihematomal cerebral edema was determined by computed tomographic scan before operation. The results of staining and the volume of perihematomal cerebral edema were analyzed with double blind fashion. Results Perihematomal cerebral edema were found 12-72h after cerebral hemorrhage. Myelin sheath degeneration, condensation of nucleus and typical apopototic body were observed in perihematomal brain tissue. Expression of cytochrome C in perihematomal brain tissue was observed at 4 h and reached peak around 48-72 h after cerebral hemorrhage. Cytochrome C expressed higher positively in 16 patients and lower positively in 13 patients. Cytochrome C expression was not detected only in 5 patints. There were significant differences in volume of perihematomal cerebral edema with different expression of cytochrome C in perihematomal brain tissue (P＜0.01). Conclusions Cytochrome C expression was upregulated in perihematomal brain tissue in patients with hypertensive cerebral hemorrhage. Cytochrome C might involve in the histopathological change and the formation of perihematomal cerebral edema.

著录项

来源
《滨州医学院学报》 |2007年第2期|81-84|共4页
作者
CAI Heng; LIU Guixiang; XU Chunsheng; LIU Qingxin; XU Xiaobo;
展开▼
作者单位

Binzhou Medical University, Binzhou 256603, Shandong Province, P. R. China;

Binzhou Medical University, Binzhou 256603, Shandong Province, P. R. China;

Binzhou Medical University, Binzhou 256603, Shandong Province, P. R. China;

Binzhou Medical University, Binzhou 256603, Shandong Province, P. R. China;

Binzhou Medical University, Binzhou 256603, Shandong Province, P. R. China;

展开▼
原文格式 PDF
正文语种 chi
中图分类神经病学与精神病学;
关键词
cerebral hemorrhage; perihematomal cerebral edema; cytochrome C;

相似文献

中文文献
外文文献
专利

Study on the relationship of cytochrome C expression and cerebral edema in perihematomal brain tissue in patients with hypertensive cerebral hemorrhage

摘要

著录项

相似文献

相关主题

期刊订阅