Objective This retrospective study was aimed to analyze the clinical diagnostic value of color Doppler ultrasonography sco-ring,resistance index(RI )and tumor marKer CA125 in differential diagnosis of benign and malignant ovarian tumors. Methods The clinical data of 99 patients with ovarian tumors received treatment in this hospital during 2009 to 2014 were retrospectively analyzed. These patients were divided into two groups according to the severity of illness,61 patients in benign group and 38 patients in malignant group. The age structure,ul-trasonic features,blood flow,FinKler ultrasound scores,RI and serum level of CA125 were compared between these 2 groups. Results The difference in age structure of patients in these two groups was statistically significant. The ultrasonic features of patients in benign group were main-ly cystic echoes,and those in malignant group were mainly cystic and solid echoes. The difference in ultrasonic features between these two groups was statistically significant. The difference in signals of blood flow between these two groups was statistically significant. The difference in results of FinKler ultrasound scores,RI and level of CA125 between these two groups was all statistically significant. The FinKler ultrasound scores and level of CA125 in patients of benign group were both lower than those of patients in malignant group,but RI was higher than that of malignant group. The sensitivity and negative predictive value of combined application of RI,FinKler scores and level of CA125 in diagnosing patients with ovarian tumors were higher than any independent detection method. Conclusion The difference in FinKler ultrasound scores,RI and level of CA125 between these two groups is significant. The specificity and sensitivity of combined application of RI,FinKler scores and serum level of CA125 in differential diagnosis of patients with ovarian tumors are high.%目的：探析彩色多普勒超声评分和血流阻力指数（RI）结合肿瘤标记物 CA125在良、恶性卵巢肿瘤中的临床诊断价值。方法分析2009年4月至2014年4月接受治疗的99例卵巢肿瘤患者的临床资料。根据卵巢肿瘤患者病情的严重程度将入选者分为良性组（61例）和恶性组（38例）。比较两组患者的年龄构成、超声表现、血流例数以及FinKler 评分、RI、CA125的检查结果。结果两组患者的年龄构成差异有统计学意义（ P <0.01）；良性患者的超声表现主要为囊性回声，而恶性患者主要是囊实性回声，两组超声表现间的差异有统计学意义（ P <0.01）；恶性组的血流信号患者比率高于良性组，差异也有统计学意义（ P <0.01）。两组患者的 FinKler 评分、RI 以及 CA125的检查结果均具有统计学差异（ P <0.05）。良性组患者的 FinKler 评分和 CA125值均比恶性组低，而 RI 值比恶性组高。联合应用 RI、Fin-Kler 评分、CA125诊断卵巢肿瘤患者的的敏感度、阴性预测值均比任何独立的检测法高。结论 RI、FinKler 超声评分和CA125在良性组和恶性组间存在明显差异，且联合应用三种方法对诊断良、恶性卵巢肿瘤的特异度及敏感度均较高。
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