Objective To explore the clinical value of combined detection of Hcy,Cys C,D-D and hs-CRP in predicting prognosis of patients with pregnancy induced hypertension.Methods A total of 105 patients with pregnancy induced hypertension treated in our hospital were selected as pregnancy induced hypertension group,and 60 single pregnant women with the same gestational age were selected as control group.The serum levels of Hcy,Cys C,D-D and hs-CRP were measured in all patients.The preeclampsia pregnancy induced hypertension patients were divided into mild preeclampsia subgroup (n =45) and severe preeclampsia subgroup (n =60) according to the blood pressure.The indicators of each group and its correlation with the degree of pre eclampsia were observed.Results The levels of Hcy,Cys C,D-D and hs-CRP in the pregnancy induced hypertension group were significantly higher than that in the control group (P ＜ 0.05).Severe preeclampsia subgroup had higher Hcy,Cys C,D-D and hs-CRP levels than mild preeclampsia subgroup (P ＜ 0.05).The joint detection of the above indicators had higher sensitivity and specificity than single detection (P ＜0.05).Conclusion The indicators of Hcy,Cys C,D-D and hs-CRP are significantly and positively correlated with the stage of preeclampsia in pregnancy induced hypertension.The sensitivity and specificity of the combined detection of Hcy,Cys C,D-D and Hs-CRP levels are significantly better than that of single detection,so it has better clinical value.%目的 探究同型半胱氨酸(Hcy)、胱抑素C(Cys C)、D-二聚体(D-D)、超敏C反应蛋白(hs-CRP)联合检测在预测妊娠高血压综合征(妊高征)患者预后的临床价值.方法 以本院进行治疗的105例妊娠高血压子痫前期患者作为妊娠高血压组,选取同时期健康相同孕周的60例单胎妊娠妇女为对照组.对所有患者的血清中Hcy、Cys C、D-D、hs-CRP水平进行测定,将处于子痫前期妊娠高血压患者根据血压情况分为2个亚组,其中轻度子痫前期组45例和重度子痫前期组60例,观察各组间以上指标的水平差异及其与子痫前期程度的相关性.结果 妊娠高血压组的Hcy、Cys C、D-D和hs-CRP各指标均显著高于对照组(P＜0.05).妊娠高血压征重度子痫前期组Hcy、Cys C、D-D和hs-CRP均显著高于轻度子痫前期组(P＜0.05).指标联合检测的灵敏度和特异性均显著高于各个项目单独检测(P＜0.05).结论 Hcy、Cys C、D-D和hs-CRP各指标与妊高征子痫前期的分期存在显著正相关,而各指标联合检测的灵敏度和特异性相比于单独的指标检测效能具有明显的优势,具有较好的临床价值.
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