目的评价玻璃体腔联合注射康柏西普及曲安奈德治疗中青年视网膜中央静脉阻塞（ CRVO）临床疗效。方法回顾性分析2014年9月至2015年11月在我院眼科诊断为CRVO中青年患者21例（21只眼），给予玻璃体注射康柏西普（ conbercept ）及曲安奈德（ triamcinolone acetonide ），对比分析治疗前及治疗后1周、1个月、3个月行视力、裂隙灯、检眼镜、眼压、荧光素眼底血管造影（ FFA）、相干光断层扫描（ OCT）等检查指标变化情况。结果21例（21只眼）患者中，治疗前及治疗后1周、1个月、3个月视力分别为0．21±0．15、0．43±0．22、0．50±0.18、0．48±0．20，治疗后与治疗前相比，视力均明显提高， P ＜0．05，其中术后视力提高＞3行者14只眼，提高1～3行者6只眼，视力无提高者1只眼，总有效率为95．2％。与治疗前比较， FFA 显示治疗后视网膜渗漏明显减轻， OCT提示视网膜下、视网膜内或视网膜色素上皮下积液明显吸收。黄斑中心凹厚度（ CRT ）治疗前及治疗后1周、1个月、3个月分别为（742．38±188．42）μm、（347．25±124．86）μm、（254．38±51．01）μm、（387．00±362．48）μm，治疗后与治疗前相比，CRT均明显减少， P ＜0．05。随访过程中，仅发现2例一过性高眼压，经局部用药后恢复正常，未见与药物有关的眼部和全身不良反应。结论玻璃体腔联合注射康柏西普及曲安奈德是有效治疗青年型CRVO的方法之一。%Objective To evaluate the effects and safety of intravitreous injection of Conbercept and triamcinolone acetonide for the treatment of central retinal vein occlusion in young adults .Methods In this retrospective study we ana-lyzed clinical outcomes of 21 young adults (21 eyes) who was diagnosed with central retinal vein occlusion in our hospital between September 2014 and November 2015 .Patients were treated with intravitreous injection of Conbercept combined and triamcinolone acetonide.Clinical data including best-corrected visual acuity (BCVA), slit lamp and funduscopy examina-tions , intraocular pressure ( IOP) , fundus fluorescein angiography ( FFA) , optical coherence tomography ( OCT) were col-lected before and 1 week, 1 month, 3 months after the treatment.Results When compared to baseline (0.21 ±0.15), BCVA significantly improved in all patients after treatment at 1 week (0.43 ±0.22), 1 month (0.50 ±0.18) and 3 months (0.48 ±0.20) ( P <0.05).BCVA improved more than 3 lines in 14 eyes, 1~3 lines in 6 eyes, and remained unchanged in 1 eye.The total effective rate therefore was 95.2%.FFA showed significant reduced rate of fluorescein leak-age.OCT showed that subretinal fluid , inter retinal fluid, or fluid of retinal pigment epithelial detachment were absorbed significantly.Central foveal thickness (CRT;in μm) were 347.25 ±124.86, 254.38 ±51.01, and 387.00 ±362.48 af-ter treatment;these values were significantly lower than baseline (742.38 ±188.42 μm).During follow-up, only 2 pa-tients experienced transient ocular hypertension and the IOP returned to normal after local medication administration .No other ocular and systemic adverse reactions were found .Conclusions Intravitreous injection of conbercept and triamcin-olone acetonide is an effective and safe way to treat central retinal vein occlusion in young adults .
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