Objective To discuss the symptoms and signs of chronic blepharitis, and to discuss the causes of mis-diagnosis. Methods The clinical data of 78 cases (156 eyes) diagnosed with chronic blepharitis were reviewed. The initial diagnosis of each case was recorded, and the causes of misdiagnosis were analyzed. Results Fifty-one cases were mis-diagnosed, among which 19 cases (24.36% ) were diagnosed as chronic conjunctivitis, 10 cases (12. 82% ) were diagnosed as dry eyes, 9 cases (11.54% ) were diagnosed as virus keratitis, 8 cases (10.26% ) were diagnosed as allergic conjunctivitis, and 5 cases (6.41% ) were diagnosed as trachoma. The misdiagnosis rate was 65.38%. Conclusions Clinically, chronic blepharitis, dry eyes and meibomian gland dysfunction can present similar symptoms and signs. These conditions often coexist and might share some common pathophysiologic process. In order to avoid misdiagnose, a careful history enquire and a focused physical examination is very important. Physicians should pay special attention to examine the patient's lid margin, meibomian gland function, and tear film.%目的 探讨慢性睑缘炎的临床症状和体征,分析误诊原因.方法 回顾78例(156只眼)最终诊断为慢性睑缘炎患者的临床资料,将早期的诊断与慢性睑缘炎的诊断标准进行对比,分析误诊原因.结果 78例患者中有51例误诊,包括慢性结膜炎19例(24.36％),干眼10例(12.82％),病毒性角膜炎9例(11.54％),过敏性结膜炎8例(10.26％),沙眼5例(6.41％),总误诊率为(65.38％).结论 临床上慢性睑缘炎和干眼、睑板腺功能障碍等在症状和体征都有相同之处,疾病的进展过程中互为因果；应重视病史的询问,详查睑缘、睑板腺、泪膜功能等,避免误诊.
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