Objective To explore the clinical feature of neonatal pertussis. Methods The clinical data of 29 neonates with pertussis admitted during 2012 to 2016 were retrospectively analyzed. Results In 29 neonates only 1 had a history of exposure to pertussis. All of the cases had paroxysmal cough (100.0%), 22 cases had vomit after cough (75.9%), 16 cases had spasmodic cough with cyanosis (55.2%), 7 cases had crow-like echo (24.1%), and 4 cases had apnea (13.8%). 15 cases had positive deep sputum culture, and totally 16 strains of pathogenic bacteria were isolated. In addition, 4 cases were combined with respiratory syncytial virus infection. All of the patients were treated with azithromycin or clindamycin. 19 cases were recovered, 8 cases improved, and 2 cases abandoned treatment. Conclusions Neonatal pertussis infection is occult, and usually has no clear contact history of pertussis. The clinical feature was mainly paroxysmal cough. The crow like echo was seldom. Pertussis cannot be completely excluded in neonates with positive respiratory syncytial virus.%目的 探讨新生儿百日咳的临床特征.方法 回顾分析2012-2016年收治的29例新生儿百日咳患儿的临床资料.结果 29例患儿中仅1例有明确百日咳患者接触史.临床表现有阵发性咳嗽29例(100.0%),咳嗽后呕吐22例(75.9%),痉挛性咳嗽伴青紫16例(55.2%),鸡鸣样回声7例(24.1%),呼吸暂停4例(13.8%).15例患儿(51.7%)深部痰培养阳性,共培养出其他病原菌16株;合并呼吸道合胞病毒感染4株.所有患儿均采用阿奇霉素或克林霉素治疗,痊愈19例,好转出院8例,放弃治疗2例.结论 新生儿百日咳传染源隐匿,往往无明确百日咳接触史;临床以阵发性咳嗽为主,少有鸡鸣样回声;呼吸道合胞病毒检测阳性者不能完全除外新生儿百日咳.
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