Objective To study the significance of interleukin-17 ( IL-17 ) and interlenkin-6 ( IL-6 ) in pe-ripheral blood and bronchoalveolar lavage fluid ( BALF ) from patients with idiopathic pulmonary fibrosis ( IPF ) . Methods The levels of IL-17 and IL-6 were determined with ELISA in serum and BALF of 31 patients with IPF ( the case group) and 14 subjects without interstitial lung diseases ( the control group) . The relationship of IL-17 and IL-6 levels with lung function was analyzed. Results The level of IL-6 in BALF of patients with IPF was significant-ly higher than that in the control group (P<0. 01), and it was higher than that in serum (P<0. 01). The level of IL-17 in BALF of patients with IPF was significantly higher than that in the control group ( P<0. 01 ) , and it was higher than that in serum (P<0. 01). The levels of IL-6 and IL-17 in serum and BALF of patient with IPF showed a strong positive correlation with pulmonary function test (P<0. 01). Conclusion The levels of IL-17 and IL-6 may play an important role in the pathogenesis of IPF and be a potential marker of IPF activity.%目的：探讨特发性肺纤维化患者支气管肺泡灌洗液和血清中白细胞介素-17( IL-17)和白细胞介素-6(IL-6)水平的变化及临床意义。方法选择：31例特发性肺纤维化患者(病例组)和14例健康就诊者(对照组)为研究对象，采用ELISA 法检测两组组BALF和外周血中IL-17和IL-6的水平，分析病例组患者IL-17和IL-6水平与其肺功能的关系。结果 IPF组患者血清和BALF中IL-6水平为均明显高于对照组水平(P<0．01)；IPF组患者血清和BALF中IL-17水平均明显高于对照组水平(P<0．01)；IPF组患者血清和BALF患者的IL-6和IL-17水平与 FVC、FEV1、 FEV1∕ FVC和 DLco水平均呈现明显的负相关性( P均<0．01)。结论 IL-17和IL-6可能在IPF的发病过程中发挥一定作用，并有可能作为判断IPF病情严重程度的一项指标。
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