目的：：探讨冠心病患者颈动脉粥样硬化的超声特征及其与病情严重程度的相关性.方法：收集在本院接受治疗的冠心病患者180例作为观察组,根据冠状动脉狭窄程度分为单支病变组50例、双支病变组72例、三支病变组58例；另取同期在本院进行体检的健康人50例作为对照组.采用颈动脉超声检测颈动脉粥样硬化参数,采用心脏彩色多普勒超声检测心功能参数,采用酶联免疫吸附法(ELISA)检测血清内皮功能指标,采用 Pearson 检验分析颈动脉超声参数与心功能、内皮功能的相关关系.结果：观察组颈动脉超声参数β、Ep、AC、PWVβ值高于对照组,随着冠脉病变程度增加,β、Ep、AC、PWVβ值改变程度加剧(P ＜0．05)；观察组心功能参数 LVEDD、LVESD 值高于对照组,LVEF 值低于对照组,随着冠脉病变程度增加,LVEDD、LVESD、LVEF 值改变程度加剧(P ＜0．05)；观察组的内皮功能指标ET-1、vWF 水平高于对照组,NO 水平低于对照组,随着冠脉病变程度增加,ET-1、vWF、NO 水平改变程度加剧(P ＜0．05).冠心病患者颈动脉超声参数β、Ep、AC、PWVβ值与心功能参数、内皮功能指标水平均呈直接相关关系.结论：冠心病患者颈动脉粥样硬化的超声参数水平与病变严重程度直接相关,可作为早期病情判断的无创、可靠手段.%[ABSTRACT]Objective:To study the ultrasound features of carotid atherosclerosis in patients with coronary heart disease and their correlation with disease severity.Methods:A total of 180 patients with coronary heart disease treated in our hospital from December 2010 to December 201 5 were collected as observation group and divided into single-vessel disease group (n =50),double-vessel disease group (n =72)and triple-vessel disease group (n =58)according to the degree of coronary artery stenosis;50 healthy subjects receiving physical examination in our hospital during the same period were selected as control group.Carotid ultrasound was used to measure carotid atherosclerosis parameters,cardiac color Doppler ultrasound was used to detect cardiac function parameters,enzyme-linked immunosorbent assay (ELISA)was used to detect serum endothelial func-tion indexes,and Pearson test was used to analyze the correlation between carotid ultrasound parameters and the cardiac func-tion as well as endothelial function.Results:Carotid ultrasound parameters β,Ep,AC and PWVβvalue of observation group were higher than those of control group,and with the increase of coronary artery lesion severity,the changes ofβ,Ep,AC and PWVβvalue increased (P <0.05 );cardiac function parameters LVEDD and LVESD value of observation group were higher than those of control group while LVEF value was lower than that of control group,and with the increase of coronary artery le-sion severity,the changes of LVEDD,LVESD and LVEF value increased (P <0.05);endothelial function indexes ET-1 and vWF levels of observation group were higher than those of control group while NO level was lower than that of control group, and with the increase of coronary artery lesion severity,the changes of ET-1,vWF and NO levels increased (P <0.05).Carotid ultrasound parameterβ,Ep,AC and PWVβvalue in patients with coronary heart disease were directly correlated with the lev-els of cardiac function parameters and endothelial function indexes.Conclusion:The ultrasound parameter levels of carotid ath-erosclerosis in patients with coronary heart disease are directly correlated with the disease severity and can be used as the nonin-vasive and reliable means for early judgment of the disease.
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