目的:探讨果糖二磷酸联合大剂量维生素C治疗对新生儿窒息后心肌氧化应激损伤的影响.方法:收集本院收治的新生儿窒息患者40例,根据双盲随机对照法将其分为接受大剂量维生素C治疗的对照组、接受果糖二磷酸联合大剂量维生素C治疗的观察组各20例,持续治疗10 d.入院即刻、治疗10 d后,采用放射免疫法测定血清氧化应激指标含量,应用彩色多普勒超声诊断仪测定左心功能参数,采用心肌酶谱检测仪测定心肌酶谱指标含量.结果:入院即刻,两组全身氧化应激程度、左心功能损伤程度及心肌酶谱指标含量差异无统计学意义.治疗10 d后,观察组血清中MDA、AOPP、CK-MB、Nt-proBNP、H-FABP、cTnⅠ含量低于对照组,SOD含量高于对照组,左心功能参数ET水平高于对照组,ICT、IRT水平低于对照组.结论:果糖二磷酸联合大剂量维生素C可减轻新生儿窒息全身氧化应激程度,减少由此产生的心肌损伤.%Objective: To study the effect of fructose diphosphate combined with large-dose vitamin C therapy on the myocardial oxidative stress injury after neonatal asphyxia.Methods: A total of 40 patients with neonatal asphyxia who were treated in our hospital between June 2013 and April 2016 were collected and divided into the control group (n=20) who received large-dose vitamin C therapy and the observation group (n=20) who received fructose diphosphate combined with large-dose vitamin C therapy according to the double-blind randomized control method, and the treatment lasted for 10 d.Immediately after admission and after 10 d of treatment, RIA method was used to detect the serum levels of oxidative stress indexes, color Doppler diasonograph was used to determine left cardiac function parameters, and the myocardial enzyme spectrum detector was used to determine myocardial enzyme spectrum index levels.Results: Immediately after admission, the differences in the systemic oxidative stress degree, the left cardiac function damage degree and the myocardial enzyme spectrum index levels were not statistically significant between two groups of patients.After 10 d of treatment, serum MDA, AOPP, CK-MB, Nt-proBNP, H-FABP and cTnⅠ contents of observation group were lower than those of control group while SOD content was higher than that of control group, and the left cardiac function parameter ET level was higher than that of control group while ICT and IRT levels were lower than those of control group.Conclusions: Fructose diphosphate combined with large-dose vitamin C can reduce the systemic oxidative stress of neonatal asphyxia and reduce the resulting myocardial injury.
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