Objective: To study the correlation of serum LAG-3 and DKK-1 levels with cancer cell proliferation, invasion, angiogenesis and other clinical pathological characteristics in patients with gastric cancer.Methods: A total of 48 patients who were diagnosed with early gastric cancer in our hospital between June 2014 and October 2016 were selected as the gastric cancer group of the research, 50 healthy volunteers who received physical examination in our hospital during the same period were selected as the control group of the research, serum was collected to determine the levels of LAG-3, DKK-1 and angiogenesis molecules, and the gastric cancer tissue and the tissue adjacent to carcinoma were collected to determine the expression of proliferation and invasion-related molecules.Results: Serum LAG-1, DKK-1, Ang-1, Ang-2, VEGF and bFGF levels of gastric cancer group were significantly higher than those of control group, and EPHA2, LOXL2, PCNA, Akt, CyclinD1, MYH-9, CXCR7, KDM1A and CatB mRNA expression in gastric cancer tissue were significantly higher than those in the tissue adjacent to carcinoma;serum Ang-1, Ang-2, VEGF and bFGF levels as well as EPHA2, LOXL2, PCNA, Akt, CyclinD1, MYH-9, CXCR7, KDM1A and CatB mRNA expression in gastric cancer tissue of patients with gastric cancer were positively correlated with serum LAG-3 and DKK-1 levels.Conclusions: Serum LAG-3 and DKK-1 levels are valuable to diagnose early gastric cancer and can assess the cancer cell proliferation, invasion, angiogenesis and other clinical pathological characteristics in gastric cancer tissue.%目的:研究胃癌患者血清中LAG-3、DKK-1含量及癌细胞增殖、侵袭、血管新生等临床病理特征的相关性.方法:选择在我院诊断为早期胃癌的48例患者作为研究的胃癌组,同期在我院体检的50例健康志愿者作为研究的对照组,采集血清并测定LAG-3、DKK-1及血管新生分子的含量,采集胃癌组织、癌旁组织并测定增殖、侵袭相关分子的表达量.结果:胃癌组血清中LAG-1、DKK-1、Ang-1、Ang-2、VEGF、bFGF的含量显著高于对照组,胃癌组织中EPHA2、LOXL2、PCNA、Akt、CyclinD1、MYH-9、CXCR7、KDM1A、CatB的mRNA表达量均显著高于癌旁组织;胃癌患者血清中Ang-1、Ang-2、VEGF、bFGF的含量及胃癌组织中EPHA2、LOXL2、PCNA、Akt、CyclinD1、MYH-9、CXCR7、KDM1A、CatB的mRNA表达量均与血清LAG-3、DKK-1含量呈正相关关系.结论:血清LAG-3、DKK-1含量对早期胃癌具有诊断价值并且能够评估胃癌组织中癌细胞增殖、侵袭及血管新生的临床病理特征.
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