Objective: To study the correlation of serum monocyte chemoattractant protein-1 (MCP-1) and vascular endothelial cadherin (VE-cadherin) levels with neural function and carotid atherosclerosis in patients with acute cerebral infarction.Methods: 78 patients who were diagnosed with acute cerebral infarction in our hospital between May 2013 and August 2016 were selected as pathological group, and 80 healthy volunteers who received physical examination in our hospital during the same period were selected as control group.Serum was collected to determine the levels of MCP-1, VE-cadherin, nerve injury molecules, inflammatory mediators, proteases and their hydrolysate.Results: Serum MCP-1, VE-cadherin, NGB, NSE, S100β, HMGB-1, sCD40L, YKL-40, visfatin, CatK, MMP9 and ICTP levels of pathological group were significantly higher than those of control group;serum MCP-1 and VE-cadherin levels of pathological group were positively correlated with NGB, NSE, S100β, HMGB-1, sCD40L, YKL-40, visfatin, CatK, MMP9 and ICTP levels.Conclusion: Serum MCP-1 and VE-cadherin levels abnormally increase in patients with acute cerebral infarction, and are closely related to the nerve injury and atherosclerosis process.%目的:研究急性脑梗塞患者血清单核细胞趋化蛋白-1(MCP-1)、血管内皮细胞钙黏蛋白(VE-cadherin)的水平与神经功能、颈动脉粥样硬化的相关性.方法:选择在我院诊断为急性脑梗塞的78例患者作为病理组,同期在我院体检的80例健康志愿者作为对照组.采集血清并测定MCP-1、VE-cadherin、神经损伤分子、炎症介质、蛋白酶及其水解产物的含量.结果:病理组患者血清中MCP-1、VE-cadherin、NGB、NSE、S100β、HMGB-1、sCD40L、YKL-40、visfatin、CatK、MMP9、ICTP的含量显著高于对照组;病理组患者血清中MCP-1、VE-cadherin的含量与NGB、NSE、S100β、HMGB-1、sCD40L、YKL-40、visfatin、CatK、MMP9、ICTP的含量呈正相关.结论:急性脑梗塞患者血清中MCP-1、VE-cadherin的含量异常升高并且与神经功能损伤、动脉粥样硬化进程密切相关.
展开▼
