Objective To analysis of the enalapril joint hydrogen chlorothiazide elderly patients with isolated systolic hypertension clinical effect and safety. Methods Hospital treatment of 78 patients over the age of 60 with isolated systolic hypertension were randomly divided into two groups, the control group, 38 patients treated with enalapril treatment, the observation group of 40 patients were treated with enalapril hydrochlorothiazide treatment were observed therapeutic effects and adverse reactions. Results The treatment of the total effective rate for the control group, the therapeutic effect of the observation group than the control group (P <0.05); After treatment, systolic blood pressure (134.5±16.4) mm Hg and the control group (143.7±18.9) mmHg, blood pressure control observation group is better than the control group (P <0.05); adverse reaction rate of the observation group, the control group, two groups the incidence of adverse reactions was no significant difference (P> 0.05). Conclusion enalapril joint hydrochlorothiazide therapy, systolic blood pressure is well controlled, adverse reactions, safe and reliable clinical application to extend the application of elderly patients with isolated systolic hypertension.%目的 分析依那普利联合氢氯噻嗪对老年单纯收缩期高血压的临床疗效及安全性.方法 将到本院治疗的78例60岁以上单纯收缩期高血压患者按随机数字表法分为两组,对照组38例单纯给予依那普利治疗,观察组40例给予依那普利联合氢氯噻嗪治疗,观察两组疗效及不良反应发生情况.结果 观察组疗效优于对照组,差异有统计学意义(P＜0.05);观察组治疗后收缩压为(134.5±16.4)mmHg,对照组为(143.7±18.9)mmHg,观察组血压控制优于对照组,差异有统计学意义(P＜0.05);两组不良反应发生率比较,差异无统计学意义(P＞0.05).结论 对老年单纯性收缩期高血压患者采用依那普利联合氢氯噻嗪治疗,收缩压控制良好,不良反应少,安全可靠,临床应推广使用.
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