Objective To explore a safety training mode for junior nurses taking health, safety and environment as target. Methods Referring to the ideas and methods of DuPont management system, basic safety education was implemented aimed at job skill training. With collaborative interdisciplinary teaching, behavior based safety observation focused on operational behavior and line management training. The training effect was assessed through daily and post review. The incidence of adverse events and the quality of nursing safety management were compared before and after the training. Results The occurrence of adverse events was significantly lower after training (P<0.01) and most events (71.6%) ended without serious damage. The qualified rate of identification and handover process quality, doctor’s advice execution and check quality, and medication safety and quality was 95.5%, 96.5%, 96.5%respectively, which was significantly higher than those before the training (P<0.01). Conclusion Giving full consideration to the features of nurses and training needs, the key of safety training for junior nurses is to remove barriers to safe behavior. Safety training, which is practical, can effectively enhance the safety consciousness of nurses and risk prevention ability.%目的：以“健康”、“安全”、“环境”为目标，探索一套低年资护士安全培训模式。方法借鉴杜邦管理体系的理念和方法，根据培训需求评定确定安全基础教育培训，提供跨学科协同教学，以岗位技能培训为主，以行为安全训练观察法关注人的操作行为，直线管理培训，以日常评估、岗位检验培训效果。比较培训前后低年资护士不良事件发生率、护理安全管理质量。结果培训后低年资护士发生不良事件明显低于培训前（P＜0.01），事件损伤结局以无伤害为主（71.6%），身份识别和交接流程质量、医嘱执行和查对制度质量、用药安全质量合格率分别为95.5%、96.5%、96.5%，明显优于培训前（P＜0.01）。结论实施低年资护士安全培训，充分考虑护士特点和培训需求，关键是消除人的不安全行为，能有效提升护士安全意识和风险防范能力，具有实用性和可操作性。
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